Pulmonary innervation, inflammation and carcinogenesis

( views:144, downloads:0 )
Author:
LIANG Yong-Jie(Department of Medicine, University of Louisville, Louisville, KY 40292, USA)
ZHOU Ping(Department of Physiology and Pathophysiology,Shanghai Medical College, Fudan University, Shanghai 200032, China)
Warangkhana WONGBA(Department of Medicine, University of Louisville, Louisville, KY 40292, USA)
Juan GUARDIOLA(Department of Medicine, University of Louisville, Louisville, KY 40292, USA)
Jerome WALKER(Department of Medicine, University of Louisville, Louisville, KY 40292, USA)
Jerry YU(Department of Medicine, University of Louisville, Louisville, KY 40292, USA;Department of Physiology and Pathophysiology,Shanghai Medical College, Fudan University, Shanghai 200032, China)
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 62, Issue 03, 2010
DOI:
Key Word:
airway sensor;vagal afferent;cancer;lung;neuroimmune

Abstract: Lung cancer is a major medical problem. Despite advances in molecular biology and pharmacology, the outcome of lung cancer treatment is unsatisfactory. Clinically, inflammation and cancer are closely associated, and, genetically, these two processes are regulated by the same gene loci. Inflammation promotes cancer formation. Increasing evidence shows that neuroimmune interaction involving inflammatory disease and the vagus nerves are crucial in the interaction. Airway sensory receptors are biosensors that detect the lung inflammatory process through various mediators and cytokines. This information is transmitted through vagal afferents to the brain and produces a host of responses that regulate the extent and intensity of inflammation. Tumor cells express receptors for neurotransmitters and provide a substrate for direct interaction with neurons. Thus, neural regulation of the immune response is targeted towards inflammation as well as tumors. The airway sensors can detect cancer-related cytokines, which provides a direct pathway to inform the brain of tumor growth. The knowledge of how these sensors may monitor tumor progression and provide neuroimmune interaction in the control of tumor development and metastasis will improve our treatment of lung cancer.

  • [1]Jemal A,Siegel R,Ward E,Hao Y,Xu J,Murray T,Thun MJ.Cancer statistics,2008.CA Cancer J Clin 2008; 58(2):71-96.
  • [2]Novaes FT,Cataneo DC,Ruiz Junior RL,Defaveri J,Michelin OC,Cataneo AJ.Lung cancer:histology,staging,treatment and survival.J Bras Pneumol 2008; 34(8):595-600.
  • [3]Otmishi P,Gordon J,El-Oshar S,Li H,Guardiola J,Saad M,Proctor M,Yu J.Neuroimmune interaction in inflammatory diseases.Clin Med Circ Respirat Pulm Med 2008; 2:35-44.
  • [4]Ekbom A,Lundegardh G,McLaughlin JK,Nyren O.Relation of vagotomy to subsequent risk of lung cancer:population based cohort study.BMJ 1998; 316(7130):518-519.
  • [5]Erin N,Akdas BG,Harms JF,Clawson GA.Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level.Regul Pept 2008; 151(1-3):35-42.
  • [6]Lee LY,Pisarri TE.Afferent properties and reflex functions of bronchopulmonary C-fibers.Respir Physiol 2001; 125(1-2):47-65.
  • [7]Yu J.Airway mechanosensors.Respir Physiol Neurobiol 2005;148(3):217-243.
  • [8]Coleridge HM,Coleridge JC,Baker DG,Ginzel KH,Morrison MA.Comparison of the effects of histamine and prostaglandin on afferent C-fiber endings and irritant receptors in the intrapulmonary airways.Adv Exp Med Biol 1978; 99:291-305.
  • [9]Lee LY,Hong JL.Involvement of prostanoids in cigarette smoking-induced pathophysiological effects in the lung.Prostaglandins Leukot Essent Fatty Acids 1999; 61(3):145-155.
  • [10]Adriaensen D,Timmermans JP,Brouns I,Berthoud HR,Neuhuber WL,Scheuermann DW.Pulmonary intraepithelial vagal nodose afferent nerve terminals are confined to neuroepithelial bodies:an anterograde tracing and confocal microscopy study in adult rats.Cell Tissue Res 1998; 293(3):395-405.
  • [11]Cutz E,Jackson A.Neuroepithelial bodies as airway oxygen sensors.Respir Physiol 1999; 115(2):201-214.
  • [12]Yu J,Lin SX,Zhang JW,Walker JF.Pulmonary nociceptors are potentially connected with neuroepithelial bodies.Adv Exp Med Biol 2006; 580:301-306.
  • [13]Veres TZ,Shevchenko M,Krasteva G,Spies E,Prenzler F,Rochlitzer S,Tschernig T,Krug N,Kummer W,Braun A.Dendritic cell-nerve clusters are sites of T cell proliferation in allergic airway inflammation.Am J Pathol 2009; 174(3):808-817.
  • [14]Mantovani A,Allavena P,Sica A,Balkwill F.Cancer-related inflammation.Nature 2008; 454(7203):436-444.
  • [15]Lu H,Ouyang W,Huang C.Inflammation,a key event in cancer development.Mol Cancer Res 2006; 4(4):221-233.
  • [16]Szlosarek P,Charles KA,Balkwill FR.Tumour necrosis factoralpha as a tumour promoter.Eur J Cancer 2006; 42(6):745-750.
  • [17]Bergers G,Benjamin LE.Tumorigenesis and the angiogenic switch.Nat Rev Cancer 2003; 3(6):401-410.
  • [18]Basile JR,Castilho RM,Williams VP,Gutkind JS.Semaphorin 4D provides a link between axon guidance processes and tumorinduced angiogenesis.Proc Natl Acad Sci U S A 2006; 103(24):9017-9022.
  • [19]Szlosarek P,Balkwill F.The inflammatory cytokine network of epithelial cancer:therapeutic implications.Novartis Found Symp 2004; 256:227-237.
  • [20]Loewen GM,Tracy E,Blanchard F,Tan D,Yu J,Raza S,Matsui S,Baumann H.Transformation of human bronchial epithelial cells alters responsiveness to inflammatory cytokines.BMC Cancer 2005; 5:145.
  • [21]Bauer AK,Malkinson AM,Kleeberger SR.Susceptbility to neoplastic and non-neoplastic pulmonary diseases in mice:genetic similarities.Am J Physiol Lung Cell Mol Physiol 2004;287(4):L685-L703.
  • [22]Laskin JJ,Sandler AB.The importance of the eicosanoid pathway in lung cancer.Lung Cancer 2003; 41 Suppl 1:S73-S79.
  • [23]Lundberg JM,Saria A.Polypeptide-containing neurons in airway smooth muscle.Annu Rev Physiol 1987; 49:557-572.
  • [24]Groneberg DA,Quarcoo D,Frossard N,Fischer A.Neurogenic mechanisms in bronchial inflammatory diseases.Allergy 2004;59(11):1139-1152.
  • [25]Fischer A,McGregor GP,Saria A,Philippin B,Kummer W.Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation.J Clin Invest 1996; 98(10):2284-2291.
  • [26]Geppetti P,Nassini R,Materazzi S,Benemei S.The concept of neurogenic inflammation.BJU Int 2008; 101 Suppl 3:2-6.
  • [27]O'Connor TM,O'Connell J,O'Brien DI,Goode T,Bredin CP,Shanahan F.The role of substance P in inflammatory disease.J Cell Physiol 2004; 201(2):167-180.
  • [28]Lee LY,Widdicombe JG.Modulation of airway sensitivity to inhaled irritants:role of inflammatory mediators.Environ Health Perspect 2001; 109 Suppl 4:585-589.
  • [29]Dunzendorfer S,Kaser A,Meierhofer C,Tilg H,Wiedermann CJ.Cutting edge:peripheral neuropeptides atract immature and arrest mature blood-derived dendritic cells.J Immunol 2001; 166(4):2167-2172.
  • [30]Tracey KJ.The inflammatory reflex.Nature 2002; 420(6917):853-859.
  • [31]Dickerson C,Undem B,Bullock B,Winchurch RA.Neuropeptide regulation of proinflammatory cytokine responses.J Leukoc Biol 1998; 63(5):602-605.
  • [32]Goehler LE,Gaykema RP,Hansen MK,Anderson K,Maier SF,Watkins LR.Vagal immune-to-brain communication:a visceral chemosensory pathway.Auton Neurosci 2000; 85(1-3):49-59.
  • [33]Lin SX,Yu J.Effects of arachidonic acid metabolites on airway sensors.Acta Physiol Sin (生理学报) 2007; 59(2):141-149.
  • [34]Yu J,Lin S,Zhang J,Otmishi P,Guardiola JJ.Airway nociceptors activated by pro-inflammatory cytokines.Respir Physiol Neurobiol 2007; 156:116-119.
  • [35]Lai CJ,Ho CY,Kou YR.Activation of lung vagal sensory receptors by circulatory endotoxin in rats.Life Sci 2002; 70(18):2125-2138.
  • [36]Lin S,Walker J,Xu L,Gozal D,Yu J.Respiratory:Behaviours of pulmonary sensory receptors during development of acute lung injury in the rabbit.Exp Physiol 2007; 92(4):749-755.
  • [37]Li HF,Yu J.Airway chemosensitive receptors in vagus nerve perform neuro-immune interaction for lung-brain communication.Adv Exp Med Biol 2009; 648:421-426.
  • [38]Proskocil BJ,Sekhon HS,Jia Y,Savchenko V,Blakely RD,Lindstrom J,Spindel ER.Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells.Endocrinology 2004; 145(5):2498-2506.
  • [39]Song P,Sekhon HS,Fu XW,Maier M,Jia Y,Duan J,Proskosil BJ,Gravett C,Lindstrom J,Mark GP,Saha S,Spindel ER.Activated cholinergic signaling provides a target in squamous cell lung carcinoma.Cancer Res 2008; 68(12):4693-4700.
  • [40]Dasgupta P,Rizwani W,Pillai S,Kinkade R,Kovacs M,Rastogi S,Banerjee S,Carless M,Kim E,Coppola D,Haura E,Chellappan S.Nicotine induces cell proliferation,invasion and epithelialmesenchymal transition in a variety of human cancer cell lines.Int J Cancer 2009; 124(1):36-45.
  • [41]Paleari L,Catassi A,Ciarlo M,Cavalieri Z,Bruzzo C,Servent D,Cesario A,Chessa L,Cilli M,Piccardi F,Granone P,Russo P.Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.Cell Prolif 2008; 41(6):936-959.
  • [42]Carlisle DL,Liu X,Hopkins TM,Swick MC,Dhir R,Siegfried JM.Nicotine activates cell-signaling pathways through muscletype and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.Pulm Pharmacol Ther 2007; 20(6):629-641.
  • [43]Gidron Y,Perry H,Glennie M.Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol 2005; 6(4):245-248.
  • [44]Caygill CP,Knowles RL,Hall R.Increased risk of cancer mortality after vagotomy for peptic ulcer:a preliminary analysis.Eur J Cancer Prev 1991; 1(1):35-37.
  • [45]Erin N,Boyer PJ,Bonneau RH,Clawson GA,Welch DR.Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart.Anticancer Res 2004;24(2B):1003-1009.
  • [46]Erin N,Zhao W,Bylander J,Chase G,Clawson G.Capsaicininduced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.Breast Cancer Res Treat 2006; 99(3):351-364.
  • [47]Harris DT,Witten M.Aerosolized substance P protects against cigarette-induced lung damage and tumor development.Cell Mol Biol (Noisy-le-grand) 2003; 49(2):151-157.
  • [48]Lucattelli M,Fineschi S,Geppetti P,Gerard NP,Lungarella G.Neurokinin-1 receptor blockade and murine lung tumorigenesis.Am J Respir Crit Care Med 2006; 174(6):674-683.
  • [49]Reeve JG,Bleehen NM.[D-Arg1,D-Phe5,D-Trp7,9,Leul1]substance P induces apoptosis in lung cancer cell lines in vitro.Biochem Biophys Res Commun 1994; 199(3):1313-1319.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn