Impaired neural coordination in hippocampus of diabetic rat

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LIU Kai(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China;Department of High-tech Innovation Centre, Institute of Automation ,Chinese Academy of Sciences,Beijing 100190,China)
XIE Kang-Ning(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China;Faculty of Biomedical Engineering,the Fourth Military Medical University,Xi'an 710032, China)
QIAO Zhi-Mei(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
GAO Shang-Kai(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
HONG Bo(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
Journal Title:
Volume 61, Issue 05, 2009
Key Word:
coherence; phase locking; local field potential; slow oscillation; diabetes mellitus; hippocampus

Abstract: In vitro electrical neurophysiological and behavioural studies have shown that diabetes mellitus negatively affects hippocampal function. In this study, by using in vivo extracellular recording, the spontaneous neural activity was obtained from hippocampus of anaesthetized rats in both streptozotocin-indueed diabetes group and normal control group. Temporal relationship between neuronal 1tiring and slow oscillation (1-4 Hz) of local field potentials (LFPs) in hippocampus was analyzed using coherence and phase locking measurement. Lower coherence value (0.617±0.028) was observed in diabetic rats than that in control rats (0.730±0.024) (P=0.005). Furthermore, phase-locking measurement using von Mises fitting parameterized by a concentration parameter k showed a lower degree (k = 0.347±0.113) of temporal coordination between neuronal spiking and slow oscillation of LFPs in the hippocampus of diabetic rats than that of normal ones (k= 1.174±0.134) (P<0.001). Both approaches demonstrated that diabetes can indeed impair the temporal coordination between neuronal spiking and slow oscillation of population activity in hippocampus. This observed neural coordination impairment may serve as a network level mechanism for diabetes-induced memory deterioration.

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