Impaired neural coordination in hippocampus of diabetic rat

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Author:
LIU Kai(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China;Department of High-tech Innovation Centre, Institute of Automation ,Chinese Academy of Sciences,Beijing 100190,China)
XIE Kang-Ning(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China;Faculty of Biomedical Engineering,the Fourth Military Medical University,Xi'an 710032, China)
QIAO Zhi-Mei(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
GAO Shang-Kai(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
HONG Bo(Department of Biomedical Engineering, School of Medicine,Tsinghua University,Beijing 100084,China)
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 61, Issue 05, 2009
DOI:
Key Word:
coherence; phase locking; local field potential; slow oscillation; diabetes mellitus; hippocampus

Abstract: In vitro electrical neurophysiological and behavioural studies have shown that diabetes mellitus negatively affects hippocampal function. In this study, by using in vivo extracellular recording, the spontaneous neural activity was obtained from hippocampus of anaesthetized rats in both streptozotocin-indueed diabetes group and normal control group. Temporal relationship between neuronal 1tiring and slow oscillation (1-4 Hz) of local field potentials (LFPs) in hippocampus was analyzed using coherence and phase locking measurement. Lower coherence value (0.617±0.028) was observed in diabetic rats than that in control rats (0.730±0.024) (P=0.005). Furthermore, phase-locking measurement using von Mises fitting parameterized by a concentration parameter k showed a lower degree (k = 0.347±0.113) of temporal coordination between neuronal spiking and slow oscillation of LFPs in the hippocampus of diabetic rats than that of normal ones (k= 1.174±0.134) (P<0.001). Both approaches demonstrated that diabetes can indeed impair the temporal coordination between neuronal spiking and slow oscillation of population activity in hippocampus. This observed neural coordination impairment may serve as a network level mechanism for diabetes-induced memory deterioration.

  • [1]Messier C.Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging.Neurobioi Aging 2005; 26 Suppl 1:26-30.
  • [2]Artola A,Kamal A,Ramakers GM,Biessels GJ,Gispen WH.Diabetes mellitns concomitantly facilitates the induction of longterm depression and inhibits that of long-term potentiation in hippocampus.Eur J Neurosci 2005; 22:169-178.
  • [3]Stranahan AM,Arumugam TV,Cutler RG,Lee K,Egan JM,Mattson MP.Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons.Nat Neurosci 2008; 11:309-317.
  • [4]Axmacher N,Mormann F,Fernandez G,Elger CE,Fell J.Memory formation by neuronal synchronization.Brain Res Rev 2006; 52:170-182.
  • [5]Buzsaki G.Them oscillations in the hippocampus.Neuron 2002; 33:325-340.
  • [6]Lenck-Santini PP,Holies GL.Altered phase precession and compression of temporal sequences by place cells in epileptic rats.J Neurosci 2008; 28:5053-5062.
  • [7]Robbe D,Montgomery SM,Thome A,Rueda-Orozco PE,McNaughton BL,Buzsaki G.Cannabinoids reveal importance of spike timing coordination in hippocampal function.Nat Neurosci 2006; 9:1526-1533.
  • [8]Schall KP,Kerber J,Dickson CT.Rhythmic constraints on hippocampal processing:state and phase-related fluctuations of synaptic excitability during them and the slow oscillation.J Neurophysiol 2008; 99:888-899.
  • [9]Wolansky T,Clement EA,Peters SR,Palczak MA,Dickson CT.Hippocampal slow oscillation:a novel EEG state and its coordination with ongoing neocortical activity.J Neurosci 2006; 26:6213-6229.
  • [10]Jarvis MR,Mitra PP.Sampling properties of the spectrum and coherency of sequences of action potentials.Neural Comput 2001; 13:717-749.
  • [11]Thomson DJ.Spectrum estimation and harmonic analysis.Proc IEEE 1982; 70:1055-1096.
  • [12]Buzsaki G,Eidelberg E.Phase relations of hippocampal projection cells and interneurons to them activity in the anesthetized rat.Brain Res 1983; 266:334-339.
  • [13]Siapas AG,Lubenov EV,Wilson MA.Prefrontal phase locking to hippocampal them oscillations.Neuron 2005; 46:141-151.
  • [14]Paxinos G,Watson C.The Rat Brain in Stereotaxic Coordinations.5th ed.San Diego:Academic Press,2004:52-66,68-90.
  • [15]Womelsdorf T,Fries P,Mitra PP,Desimone R.Gamma-band synchronization in visual cortex predicts speed of change detection.Nature 2006; 439:733-736.
  • [16]Kramis R,Vanderwolf CH,Bland BH.Two types of hippocampal rhythmical slow activity in both the rabbit and the rat:relations to behavior and effects of atropine,diethyl ether,urethane,and pentobarbital.Exp Neurol 1975; 49:58-85.
  • [17]Maquet P.The role of sleep in learning and rnemory.Science 2001; 294:1008-1052
  • [18]Rasch B,Btichel C,Gais S,Born J.Odor cues during slow-wave sleep prompt declarative memory consolidation.Science 2007;315:1426-1429.
  • [19]Kamal A,Biessels GJ,Duis SE,Gispen WH.Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats:interaction of diabetes and ageing.Diabetologia 2000; 43:500-506.
  • [20]Gao J,Sui JF,Zhu ZR,Chen PH,Wu YM.Spontaneous discharges of pyramidal cells in the dorsal hippocampus of guinea pig.Acta Physiol Sin (生理学报) 2005; 57(2):181-187.
  • [21]Uhlhaas PJ,Singer W.Neural synchrony in brain disorders:relevance for cognitive dysfunctions and pathophysiology.Neuron 2006; 52:155-168.
  • [22]Martinez-Tellez R,Gómez-Villalobos Mde J,Flores G.Alteration in dendritic morphology of cortical neurons in rats with diabetes mellitus induced by streptozotocin.Brain Res 2005;1048:108-115.
  • [23]Dan Y,Poo MM.Spike timing-dependent plasticity:from synapse to perception.Physiol Rev 2006; 86:1033-1048.
  • [24]Chen L,Han TZ,Jiang ML.Different glutamate receptor mechanisms in long-term depression induced by different stimulus patterns in the CA1 area of adult rat hippocampus.Acta Physiol Sin (生理学报) 2008; 60(2):270-274.
  • [25]Jin XC,Ma CL,Li BM.The alpha_2A-adrenoceptor agonist guanfacine improves spatial learning but not fear conditioning in rats.Acta Physiol Sin (生理学报) 2007; 59(6):739-744.
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