Inhalation of aminoguanidine prevents the up-regulation of connective tissue growth factor in fibrotic lungs of rats

( views:, downloads: )
Author:
GUO Hong()
CHEN Xiao-Ling()
CHEN Chao()
JIN Hui()
LI Shu-Qin()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 61, Issue 04, 2009
DOI:
Key Word:

Abstract:

  • [1]Chen XL,Li WB,Zhou AM,Ai J,Huang SS.Role of endogenous peroxynitrite in pulmonary injury and fibrosis induced by bleomycin A5 in rats.Acta Pharmacol Sin 2003; 24(7):697-702.
  • [2]Chen XL,Huang SS,Li WB,Wang DH,WangXL.Inhibitory effect of aminoguanidine on bleomycin-induced pulmonary toxicity in rat.Acta Pharmacol Sin 2001; 22 (8):711-715.
  • [3]Leask A,Holmes A,Abraham DJ.Connective tissue growth factor:a new and important player in the pathogenesis of fibrosis.Curr Rheumatol Rep 2002; 4(2):136-142.
  • [4]Lasky JA,Ortiz LA,Tonthat B,Hoyle GW,Corti M,Athas G,Lungarella G,Brody A,Friedman M.Connective tissue growth factor mRNA expression is upregulated in bleomycininduced lung fibrosis.Am J Physiol 1998; 275(2):L365-L371.
  • [5]Huang YM (黄研敏),Chen XL,Xu N,Liu W,Qi J,Liu JH,Ai J.Effect of Ginkgo biloba extract on the expression of connective tissue growth factor in the initiating stage of fibrosis in lungs of rats.Chin J Pathophysiol (中国病理生理杂志) 2007; 23(6):1130-1132 (Chinese,English abstract).
  • [6]Wani J,Carl M,Henger A,Nelson PJ,Rupprecht H.Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells.Biol Chem 2007; 388(5):497-506.
  • [7]Chen XL,Huang SS,Liu Kun,Ai Jie.Modulatory action of endogenous and exogenous nitric oxide on survival of alveolar macrophages from normal and bleomycin-treated rats.Acta Physiol Sin (生理学报) 2005; 57(5):619-626.
  • [8]Chujo S,Shirasaki F,Kawara S,Inagaki Y,Kinbara T,Inaoki M,Takigawa M,Takehara K.Connective tissue growth factor causes persistent proalpha2(Ⅰ) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model.J Cell Physiol 2005; 203(2):447-456.
  • [9]Mori T,Kawara S,Shinozaki M,Hayashi N,Kakinuma T,Igarashi A,Takigawa M,Nakanishi T,Takehara K.Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis:A mouse fibrosis model.J Cell Physiol 1999; 181 (1):153-159.
  • [10]Saleh D,Barnes PJ,Giaid A.Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis.Am J Respir Crit Care Med 1997; 155(5):1763-1769.
  • [11]Chen XL (陈晓玲),Li YM,Huang SS,Wang DH,Li WB.The augmentative effect of inducible nitric oxide synthase on pulmonary fibrosis progression.Chin J Pathophysiol (中国病理生理杂志) 2002; 18(10):1251-1253 (Chinese,English abstract).
  • [12]Girl SN,Biting I,Nguyen T,Wang Q,Hydeb DM.Abrogation of bleomycin-induced lung fibrosis by nitric oxide synthase inhibitor,aminoguanidine in mice.Nitric Oxide 2002; 7(2):109-118.
  • [13]Yildirim Z,Turkoz Y,Kotuk M,Armutcu F,Gurel A,Iraz M,Ozen S,Aydogdu I,Akyol O.Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats.Nitric Oxide 2004; 11(2):156-165.
  • [14]Chen XL (陈晓玲),Huang SS,Li YM,Li WB,Wang XL,Wang QH.The kinetic alteration of nitric oxide formation in the lungs in the development of pulmonary fibrosis of rats.Chin J Pathophysiol (中国病理生理杂志) 2001; 17(6):534-537 (Chinese,English abstract).
  • [15]Twigg SM,Cao Z,MCLennan SV,Bums WC,Brammar G,Forbes JM,Cooper ME.Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.Endocrinology 2002; 143 (12):4907-4915.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn