Potassium channels and proliferation and migration of breast cancer cells

( views:172, downloads:0 )
Author:
ZHANG Lei(College of Life Science,Liaoning Normal University,Dalian 116029,China)
ZOU We(College of Life Science,Liaoning Normal University,Dalian 116029,China)
ZHOU Shi-Sheng(Medical College of Dalian University,Dalian 116600,China)
CHEN Dong-Dong(College of Life Science,Liaoning Normal University,Dalian 116029,China)
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 61, Issue 01, 2009
DOI:
Key Word:
potassium channels;breast cancer;proliferation;metastasis

Abstract: Potassium channels (K+channels), a family of special ion channel proteins, are involved in various physiological functions, Recent data show that the abnormalities of K+ channels are not only responsible for some neurological and cardiovascular diseases but also for channelopathies. Furthermore, many groups reported that the abnormalities of K+ channels had shown their oncogenic potential in breast introduction and other malignant tumors, promoting proliferation, invasion and metastasis. The aim of this review is to give an updated introduction of research progress in K+ channels associated with breast cancer.

  • [1]Fraser SP,Diss JK,Chioni AM,Mycielska ME,Pan H,Yamaci RF,Pani F,Siwy Z,Krasowska M,Grzywna Z,Brackenbury WJ,Theodorou D,Koyutürk M,Kaya H,Battaloglu E,De Bella MT,Slade MJ,Tolhurst R,Palmieri C,Jiang J,Latchman DS,Coombes RC,Djamgoz MB.Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.Clin Cancer Res 2005; 11(15):5381-5389.
  • [2]Kunzelmann K.Ion channels and cancer.J Membr Bio12005; 205(3):159-173.
  • [3]Wang Z.Roles of K+ channels in regulating tumour cell proliferation and apoptosis.Pflugers Arch 2004; 448(3):274-286.
  • [4]Ouadid-Ahidouch H,Ahidouch A.K+ channel expression in human breast cancer cells:involvement in cell cycle regulation and carcinogenesis.J Membr Bio12008; 221(1):1-6.
  • [5]Shieh CC,Coghlan M,Sullivan JP,Gopalakrishnan M.Potassium channels:molecular defects,diseases,and therapeutic opportunities.Pharmacol Rev 2000; 52(4):557-594.
  • [6]Brevet M,Ahidouch A,Sevestre H,Merviel P,El Hiani Y,Robbe M,Ouadid-Ahidouch H.Expression of K+ channels in normal and cancerous human breast.Histol Histopathol 2008; 23(8):965-972.
  • [7]Patel AJ,Lazdunski M.The 2P-domain K+ channels:role in apoptosis and tumorigenesis.Pflugers Arch 2004; 448(3):261-273.
  • [8]Bleich M,Shan QX.Epithelial K+ channels:driving force generation and K+ recycling for epithelial transport with physiological and clinical implications.Acta Physiol Sin (生理学报) 2007; 59(4):443-453.
  • [9]Mu D,Chen L,Zhang X,See LH,Koch CM,Yen C,Tong JJ,Spiegel L,Nguyen KC,Servoss A,Peng Y,Pei L,Marks JR,Lowe S,Hoey T,Jan LY,McCombie WR,Wigler MH,Powers S.Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.Cancer Cell 2003; 3(3):297-302.
  • [10]Pei L,Wiser O,Slavin A,Mu D,Powers S,Jan LY,Hocy T.Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.Proc Natl Acad Sci USA 2003; 100(13):7803-7807.
  • [11]Pardo LA,del Camino D,Sánchez A,Alves F,Brüggemann A,Beckh S,Stühmer W.Oncogenic potential of EAG K+ channels.EMBO J 1999; 18(20):5540-5547.
  • [12]Pardo LA,Contreras-Jurado C,Zientkowska M,Alves F,Stühmer W.Role of voltage-gated potassium channels in cancer.J Membr Biol 2005; 205(3):115-124.
  • [13]Ouadid-Ahidouch H,Chaussade F,Roudbaraki M,Slomiarmy C,Dewailly E,Delcourt P,Prevarskaya N.Kvl.1 K+ channels identification in human breast carcinoma cells:involvement in cell proliferation.Biochem Biophys Res Commun 2000; 278(2):222-277.
  • [14]Abdul M,Santo A,Hoosein N.Activity of potassium channelblockers in breast cancer.Anticancer Res 2003; 23(4):3347-3351.
  • [15]Ouadid-Ahidouch H,Rondbaraki M,Ahidouch A,Delcourt P,Prevarskaya N.Cell-cycle-dependent expression of the large Ca2+-activated K+ channels in breast cancer cells.Biochem Biophys Res Commun 2004; 316(1):244-251.
  • [16]Roger S,Potier M,Vandier C,Le Guennec JY,Besson P.Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells.Biochim Biophys Acta 2004; 1667(2):190-199.
  • [17]Ouadid-Ahidouch H,Roudbaraki M,Delcourt P,Ahidouch A,Joury N,Prevarskaya N.Functional and molecular identification of intermediate-conductance Ca2+-activated K+ channels in breast cancer cells:association with cell cycle progression.Am J Physiol Cell Physiol 2004; 287(1):C125-C134.
  • [18]Woodfork KA,Wonderlin WF,Peterson VA,Strobl J S.Inhibition of ATP-sensitive potassium channels causes reversible cell-cycle arrest of human breast cancer cells in tissue culture.J Cell Physiol 1995; 162(2):163-171.
  • [19]Wonderlin WF,Woodfork KA,Strobl JS.Changes in membrane potential during the progression of MCF-7 human mammary tumor cells through the cell cycle.J Cell Physiol 1995; 165(1):177-185.
  • [20]Klimatcheva E,Wonderlin WF.An ATP-sensitive K+ current that regulates progression through early G1 phase of the cell cycle in MCF-7 human breast cancer cells.J Membr Biol 1999; 171(1):35-46.
  • [21]Borowiec AS,Hague F,Hadr N,Guénin S,Guerineau F,Gouilleux F,Roudbaraki M,Lassoued K,Ouadid-Ahidonch H.IGF-1 activates hEAG K+ channels through an Akt-dependent signaling pathway in breast cancer cells:role in cell proliferation.J Cell Physiol 2007; 212(3):690-701.
  • [22]Zhou Q,Kwan HY,Chan HC,Chan HC,Jiang JL,Tam SC,Yao X.Blockage of voltage-gated K+ channels inhibits adhesion and proliferation of hepatocarcinoma cells.Int J Mol Med 2003; 11 (2):261-266.
  • [23]Yao X,Kwan HY.Activity of voltage-gated K+ channels is associated with cell proliferation and Ca2+ influx in carcinoma cells of colon cancer.Life Sci 1999; 65 (1):55-62.
  • [24]Rouzaire-Dubois B,Dubois JM.K+ channel block-induced mammalian neuroblastoma cell swelling:a possible mechanism to influence proliferation.J Physiol 1998; 510(1):93-102.
  • [25]Ronzaire-Dubois B,Milandri JB,Bostel S,Dubois JM.Control of cell proliferation by cell volume alterations in rat C6 glioma cells.Pflugers Arch 2000; 440 (6):881-888.
  • [26]Coiret G,Matifat F,Hague F,Ouadid-Ahidouch H.17-betaestradiol activates maxi-K channels through a non-genomic path-way in human breast cancer cells.FEBS Lett 2005; 579(14):2995-3000.
  • [27]Coiret G,Borowiec AS,Madot P,Ouadid-Ahidouch H,Matifat F.The antiestrogen tamoxifen activates BK channels and stimulates proliferation of MCF-7 breast cancer cells.Mol Pharmacol 2007; 71(3):843-851.
  • [28]Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 2006; 5(11):2946-2953.
  • [29]Stringer BK,Cooper AG,Shepard SB.Overexpression of the Gprotein inwardly rectifying potassium channel 1 (GIRK1) in primary breast carcinomas correlates with axillary lymph node metastasis.Cancer Res 2001; 61(2):582-588.
  • [30]Plummer HK 3rd,Yu Q,Cakir Y,Schuller HM.Expression of inwardly rectifying potassium channels (GIRKs) and beta-adrenergic regulation of breast cancer cell lines.BMC Cancer 2004; 4:93.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn