Endoplasmic reticulum stress and myocardial hypertrophy

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LIU Xiu-Hua()
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Volume 61, Issue 01, 2009
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  • [1]Krauser DG,Devereux RB.Ventricular hypertrophy and hypertension:prognostic elements and implications for management.Herz 2006; 31:305-316.
  • [2]Pahl HL.Signal transduction from the endoplasmic reticulum to the cell nucleus.Physiol Rev 1999; 79(3):683-701.
  • [3]Liu XH (刘秀华).Progress in endogenous cardioprotection induced by ischemia postconditioning.Acta Physiol Sin (生理学报) 2008; 59(5):628-634 (Chinese,English abstract).
  • [4]Paid HL,Baeuerle PA.A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.EMBO J 1995; 14(11):2580-2588.
  • [5]Brown MS,Goldstein JL.The SREBP pathway:regulation of cholesterol metabolism by proteolysis of a membranebound transcription factor.Cell 1997; 89(3):331-340.
  • [6]Glembotski CC.The role of the unfolded protein response in the heart.Mol Cell Cardiol 2008; 44(3):453-459.
  • [7]Shi Y,Vattem KM,Sood R,An J,Liang J,Stramm L,Wek RC.Identification and characterization of pancreatic eukatyotic initiation factor 2 alpha-subunit kinase PEK,involved in translational control.Mol Cell Biol 1998; 18(12):7499-7509.
  • [8]Liu CY,Schroder M,Kaufman RJ.Ligand-independent dimer ization activates the stress-response kinases IRE 1 and PERK in the lumen of the endoplasmic reticulum.J Biol Chem 2000; 275(32):24881-24885.
  • [9]Novoa I,Zeng H,Harding I-IP,Ron D.Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α.J Cell Biol 2001; 153(5):1011-1022.
  • [10]Okamura K,Kimata Y,Higashio H,Tsuru A,Kohno K.Dissociation of Kar2p/BiP from an ER sensory molecule,Irelp,triggers the unfolded protein response in yeast.Biochem Biophys Res Commun 2000; 279(2):445-450.
  • [11]Xu FF (徐菲菲),Liu XH,Zhu XM.Calreticulin upregulation induced by hypoxic preconditioning relieves oxidative stress injury in rat cardiomyocytes.Acta Physiol Sin (生理学报) 2008; 60(1):29-37 (Chinese,English abstract).
  • [12]Li SY,Ren J.Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy:Role of insulin signaling and ER stress.J Mol Cell Cardiol 2008; 44(6):979-982.
  • [13]Okada K,Minamino T,Tsukamoto Y,Liao Y,Tsukamoto O,Takashima S,Hirata A,Fujita M,Nagamachi Y,Nakatani T,Yutani C,Ozawa K,Ogawa S,Tomoike H,Hori M,Kitakaze M.Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction:possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis.Circulation 2004; 110(6):705-712.
  • [14]Tsutsui H,Ishibashi Y,Imanaka-Yoshida K,Yamamoto S,Yoshida T,Sugimachi M,Urabe Y,Takeshita A.Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy.Am J Physiol 1997; 272 (1Pt2):H168-H175.
  • [15]Zwadlo C,Borlak J.Disease-associated changes in the expression of ion channels,ion receptors,ion exchangers and Ca2+-handling proteins in heart hypertrophy.Toxicol Appl Pharmacol 2005; 207(3):244-256.
  • [16]Hamada H,Suzuki M,Yuasa S,Mimura N,Shinozuka N,Takada Y,Suzuki M,Nishino T,Nakaya H,Koseki H,Aoe T.Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice.Mol Cell Biol 2004; 24(18):8007-8017.
  • [17]Brostrom MA,Mourad F,Brostrom CO.Regulated expression of GRP78 during vasopressin-induced hypertrophy of heart-derived myocytes.J Cell Biochem 2001; 83(2):204-227.
  • [18]Azfer A,Nin J,Rogers LM,Adamski FM,Kolattukndy PE.Activation of endoplasmic reticulum stress response during the development of ischemic heart disease.Am J Physiol Heart Circ Physiol 2006; 291(3):H1411-H1420.
  • [19]Gramolini AO,Kislinger T,Alikhani-Koopaei R,Fong V,Thompson N J,Issedin R,Sharma P,Oudit GY,Tfiviefi MG,Fagan A,Kannan A,Higgins DG,Huedig H,Hess G,Arab S,Seidman JG,Seidman CE,Frey B,Perry M,Backx PH,Liu PP,MacLennan DH,Emili A.Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.Mol Cell Proteomics 2008; 7(3):519-533.
  • [20]Peng X,Wu X,Druso JE,Wei H,Park AY,Kraus MS,Alcaraz A,Chen J,Chien S,Cerione RA,Guan JL.Cardiac developmental defects and eccentric fight ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.Proc Natl Acad Sci USA 2008; 105(18):6638-6643.
  • [21]Leatherbury L,Yu Q,Chatterjee B,Walker DL,Yu Z,Tian X,Lo CW.A novel mouse model of X-linked cardiac hypertrophy.Am J Physiol Heart Circ Physio12008; 294(6):H2701-H2711.
  • [22]Maron B J,Ferrans V J,Roberts WC.Ultrastructural features of degenerated cardiac muscle cells in patients with cardiac hypertrophy.Am J Pathol 1975; 79(3):387-434.
  • [23]Goldberg AL.Protein degradation and protection against misfolded or damaged proteins.Nature 2003; 426:895-899.
  • [24]Powell SR.The ubiquitin-proteasome system in cardiac physiology and pathology.Am J Physiol Heart Circ Physiol 2006; 291:H1-H19.
  • [25]Depre C,Wang Q,Yan L,Hedhli N,Peter P,Chen L,Hong C,Hittinger L,Ghaleh B,Sadoshima J,Vamer DE,Vatner SF,Madura K.Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy.Circulation 2006; 114:1821-1828.
  • [26]Mao W,Iwai C,Liu J,Sheu SS,Fu M,Liang CS.Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways.Mol Cell Cardiol 2008; 45(2):250-260.
  • [27]McCullough KD,Martindale JL,Klotz LO,Aw TY,Holbrook NJ.Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state.Mol Cell Biol 2001; 21(4):1249-1259.
  • [28]Zinszner H,Kuroda M,Wang X,Batchvarova N,Lighffoot RT,Remotti H,Stevens JL,Ron D.CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.Genes Dev 1998; 12(7):982-995.
  • [29]Friedman AD.GADD153/CHOP,a DNA damage-inducible protein,reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.Cancer Res 1996; 56(14):3250-3256.
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