Paper - WANFANG MED ONLINE

You Position: Home > Paper

Cell adhesion and synaptogenesis

( views:136, downloads:5 )

Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 6

DOI:: 10.3321/j.issn:0371-0874.2007.06.003

Key Word:: 突触发生;细胞黏附;突触组装;synaptogenesis;cell adhesion;synapse assembly

Abstract： Synapses are inter-neuronal connections that are fundamental working units in neural networks.How synapses are molecularly constructed is a fascinating question,which attracted scientists'attention for many decades.Neuromuscular junction,a field pioneered by Te-Pei FENG and many others,has been an excellent model for studying synaptogenesis and paved the way for our understanding of the synapse formation in the central nervous system.Recent studies shed new light on the molecular mechanisms of central synapse formation by discovering a group of cell adhesion molecules exerting potent synaptogenic effects.This review will focus on those cell adhesion molecules which can induce central synapse formation when expressed in non-neuronal cells.

Reference

[1]M, Irie,Y, Hata,M, Takeuchi,etc.Binding of neuroligins to PSD-95.[J].1997,277(5331).
[2]Prange O,Wong TP,Gerrow K,etc.A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin[J].2004,101(38).
[3]Washbourne P,McAllister AK,Bennett JE.Rapid recruitment of NMDA receptor transport packets to nascent synapses.[J].2002,5(8).
[4]H V, Friedman,T, Bresler,C C, Garner,etc.Assembly of new individual excitatory synapses: time course and temporal order of synaptic molecule recruitment.[J].2000,27(1).
[5]Butz S,Sudhof TC,Hata Y.CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.[J].1996,16(8).
[6]E, Fransen,G, Van Camp,L, Vits,etc.L1-associated diseases: clinical geneticists divide, molecular geneticists unite.[J].1997,6.
[7]Richard Torres,Bonnie L Firestein,Hualing Dong,etc.PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands[J].1998,21(6).
[8]Biederer T,Sudhof TC.Mints as adaptors. Direct binding to neurexins and recruitment of munc18.[J].2000,275(51).
[9]Onizuka M,Kitamura T,Kanbe T,etc.TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.[J].2001,27(4).
[10]Varoqueaux F,Brose N,Jamain S.Neuroligin 2 is exclusively localized to inhibitory synapses[J].2004,83(9).
[11]Hughes EG,Dalva MB,Kayser MS,etc.Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.[J].2006,26(47).
[12]Gollan L,Scheiffele P,Chih B.Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex.[J].2006,51(2).
[13]Shiosaka S,Tamura H,Yamasaki H,etc.NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin.[J].2003,23(21).
[14]P M, Wood,M, Schachner,R P, Bunge.Inhibition of Schwann cell myelination in vitro by antibody to the L1 adhesion molecule.[J].1990,10(11).
[15]Garner CC,Ziv NE,Zhai RG,etc.Molecular mechanisms of CNS synaptogenesis.[J].2002,25(5).
[16]G, Rudenko,T, Nguyen,Y, Chelliah,etc.The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.[J].1999,99.
[17]Qi JS,Chen G,Dong N.Molecular reconstitution of functional GABAergic synapses with expression of neuroligin-2 and GABA(A) receptors[J].2007,35(1).
[18]Monden M,Itoh S,Satoh K,etc.Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.[J].2003,278(37).
[19]Peck M,Aoki C,Dobler E,etc.Silencing of neuroligin function by postsynaptic neurexins.[J].2007,27(11).
[20]Winterhalter KH.,Gloor SM.,Frei K.,etc.Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression[J].2001,356(Pt.2).
[21]Ho WH,Rosenthal A,Gurney A,etc.The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.[J].2003,6(12).
[22]Wong TP,Huang K,Kang R,etc.Neuroligins mediate excitatory and inhibitory synapse formation - Involvement of PSD-95 and neurexin-1 beta in neuroligin-induced synaptic specificity[J].2005,280(17).
[23]Niimi K,Itohara S,Nakashiba T,etc.Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments[J].2007,104(37).
[24]Sheng M.Molecular organization of the postsynaptic specialization.[J].2001,98(13).
[25]Himanen JP,Nikolov DB,Geleick D,etc.Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.[J].2004,7(5).
[26]Burette A,Kim K,Kim E,etc.NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation.[J].2006,9(10).
[27]Schillaci D,Melchiorri D,Patane M,etc.Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.[J].2006,98(1).
[28]Liebl DJ,Morris CJ,Henkemeyer M,etc.mRNA expression of ephrins and Eph receptor tyrosine kinases in the neonatal and adult mouse central nervous system.[J].2003,71(1).
[29]J R, Sanes,J W, Lichtman.Development of the vertebrate neuromuscular junction.[J].1999,22.
[30]Sudhof TC,Tabuchi K.Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.[J].2002,79(6).
[31]Mari A, Takasu,Matthew B, Dalva,Richard E, Zigmond,etc.Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors.[J].2002,295(5554).
[32]Flanagan,JG,Vanderhaeghen,P.The ephrins and Eph receptors in neural development.[J].1998,21.
[33]B, Ullrich,Y A, Ushkaryov,T C, Südhof.Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons.[J].1995,14(3).
[34]Nakashiba T,Ikeda T,Nishimura S,etc.Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins.[J].2000,20(17).
[35]T, Brümmendorf,S, Kenwrick,F G, Rathjen.Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations.[J].1998,8(1).
[36]Scholl FG,Scheiffele P.Making connections: cholinesterase-domain proteins in the CNS.[J].2003,26(11).
[37]Yutaka Hata,Bazbek Davletov,Alexander G. Petrenko,etc.Interaction of synaptotagmin with the cytoplasmic domains of neurexins[J].1993,10(2).
[38]Kamiguchi H,Lemmon V.Recycling of the cell adhesion molecule L1 in axonal growth cones.[J].2000,20(10).
[39]Brose N,Gottmann K,Zhang W,etc.Neuroligins determine synapse maturation and function.[J].2006,51(6).
[40]Ortinski P,Washbourne P,Fu Z,etc.Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors.[J].2003,90(6).
[41]Dean C,Isacoff E,Scholl FG,etc.Neurexin mediates the assembly of presynaptic terminals.[J].2003,6(7).
[42]Christine I. Nam,Lu Chen.Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter[J].2005,102(17).
[43]Taylor JSH.,Soriano P.,Cohen NR.,etc.Errors in corticospinal axon guidance in mice lacking the neural celladhesion molecule L1[J].1998,8(1).
[44]Toshiaki Nakashiba,Shigeyoshi Itohara,Toshio Ikeda,etc.Complementary expression and neurite outgrowth activity of netrin-G subfamily members[J].2002,111(issues 1).
[45]Burden Gulley SM,Payne HR,Lemmon V.Growth cones are actively influenced by substrate-bound adhesion molecules.[J].1995,15(6).
[46]Rose SP.Cell-adhesion molecules, glucocorticoids and long-term-memory formation.[J].1995,18(11).
[47]Biederer T,Mozhayeva MG,Atasoy D,etc.Selective capability of SynCAM and neuroligin for functional synapse assembly.[J].2005,25(1).
[48]Yoshihara F,Ooashi N,Bennett V,etc.L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow.[J].2003,163(5).
[49]Taylor P,Boucard AA,Comoletti D,etc.A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.[J].2005,48(2).
[50]Yehezkel Ben-Ari.Excitatory actions of GABA during development: the nature of the nurture[J].2002,3(9).
[51]El Husseini A,Sala C,Nabi SM,etc.A preformed complex of postsynaptic proteins is involved in excitatory synapse development.[J].2006,49(4).
[52]Krueger SR,Fitzsimonds RM,Kolar A.The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons.[J].2003,40(5).
[53]Gibson JR,Atasoy D,Etherton MR,etc.Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.[J].2007,54(6).
[54]Zhai RG,Vardinon Friedman H,Cases Langhoff C,etc.Assembling the presynaptic active zone: a characterization of an active one precursor vesicle.[J].2001,29(1).
[55]Biederer T.Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules.[J].2006,87(1).
[56]Cline HT.Dendritic arbor development and synaptogenesis.[J].2001,11(1).
[57]Senoo H,Toyama Y,Kojima N,etc.Oligo-astheno-teratozoospermia in mice lacking RA175/TSLC1/SynCAM/IGSF4A, a cell adhesion molecule in the immunoglobulin superfamily.[J].2006,26(2).
[58]Horresh I,Sarig-Nadir O,Milo R,etc.A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.[J].2007,10(7).
[59]Sumita K,Kawata A,Sato Y,etc.Synaptic scaffolding molecule (S-SCAM) membrane-associated guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons.[J].2007,100(1).
[60]Ngo M,Itkis OS,Henkemeyer M,etc.Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.[J].2003,163(6).
[61]Craig C. Garner,Noam E. Ziv.Cellular and Molecular Mechanisms of Presynaptic Assembly[J].2004,5(5).
[62]strazeneca.com,Kullander K,Klein R.Mechanisms and functions of eph and ephrin signalling.[J].2002,3(7).
[63]Triana-Baltzer GB,Berg DK,Liu ZP.Pre- and postsynaptic actions of L1-CAM in nicotinic pathways[J].2006,33(2).
[64]S E, Ahmari,J, Buchanan,S J, Smith.Assembly of presynaptic active zones from cytoplasmic transport packets.[J].2000,3(5).
[65]Hayashi Y,Kim MJ,Futai K,etc.Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.[J].2007,10(2).
[66]M B, Dalva,M A, Takasu,M Z, Lin,etc.EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.[J].2000,103(6).
[67]Ichtchenko K.,Nguyen T.,Sudhof T. C..Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins[J].1996.
[68]Clarissa L, Waites,Ann Marie, Craig,Craig C, Garner.Mechanisms of vertebrate synaptogenesis.[J].2005,28.
[69]Robert H.Scannevin,Richard L.Huganir.Postsynaptic Organization and Regulation of Excitatory Synapses[J].2000,1(2).
[70]Y, Dan,Y, Lo,M M, Poo.Plasticity of developing neuromuscular synapses.[J].1995,105.
[71]J Q, Davis,V, Bennett.Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules.[J].1994,269.
[72]K, Ichtchenko,Y, Hata,T, Nguyen,etc.Neuroligin 1: a splice site-specific ligand for beta-neurexins.[J].1995,81(3).
[73]Chen G,Trombley PQ,van den Pol AN.Excitatory actions of GABA in developing rat hypothalamic neurones.[J].1996,494(Pt.2).
[74]S J, Holland,E, Peles,T, Pawson,etc.Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta.[J].1998,8.
[75]Song JY,Ichtchenko K,Sudhof TC,etc.Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.[J].1999,96(3).
[76]Khalilov I,Gozlan H,Represa A,etc.Interneurons set the tune of developing networks.[J].2004,27(7).
[77]Deng L,Yao J,Fang C,etc.Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures.[J].2007,27(40).
[78]Ohtsuka T,Kakunaga S,Itoh S,etc.Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes[J].2005,118(6).
[79]Cheng L,Itoh K,Lemmon V.L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region.[J].2005,25(2).
[80]David G,Reekmans G,Grootjans JJ,etc.Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin.[J].2000,275(26).