Imaging the neuromuscular junction over the past centuries

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Author:
Ju Lu(Department of Molecular and Cellular Biology,Harvard University,Cambridge,MA 02138,USA)
Jeff W.Lichtman(Department of Molecular and Cellular Biology,Harvard University,Cambridge,MA 02138,USA)
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 59, Issue 06, 2007
DOI:
Key Word:
neuromuscularjunction;imaging technique;nicotinic acetylcholine receptor;synaptic vesicle release;development

Abstract: The neuromuscularjunction(NMJ)has been studied for over a century as a model system for synaptic anatomy,physiology and development.Much of our knowledge of the NMJ has been obtained through imaging techniques,some of which were developed particularly to visualize this synapse's structure and function.In this paper we review the historical development of research on some key aspects of the NMJ,including its structure,nicotinic acetylcholine receptor distribution,the process of synaptic vesicle release,and its development.

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