Regulation of pancreatic β-cell function by adipocytes
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.2007.03.001
- Key Word:
- 脂肪因子;胰岛素;β细胞;糖尿病;adipokines;insulin;β-cells;diabetes
Abstract： Adipokines,the bioactive factors derived mainly from adipocytes, regulate pancreatic β-cell function including insulin secretion,gene expression and apoptosis.In this review,we propose that adipokines influence β-cell function through three interdependent pathways.The first is through regulating lipid and glucose metabolism in β-cells.The second implicates the change of ion channel opening and closing in β-cells.The third pathway is via the modification of insulin sensitivity of β -cells.The endocrine function of adipocytes is dynamic,and the secretion of various adipokines changes under different metabolic conditions.During the progression from the normal state to obesity and to type 2 diabetes,adipokines contribute to the occurrence and development of β-cell dysfunction in type 2 diabetes.
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