H2S and cellular proliferation and apoptosis

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Author:
YANG Guang-Dong()
WANG Rui()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 59, Issue 02, 2007
DOI:
Key Word:
H2S;gasotransmitter;cystathionine γ-lyase;proliferation;apoptosis

Abstract: Hydrogen sulfide (H2S) is among a family of endogenous molecules of gas, defined as gasotransmitters. In recent years,endogenous production of H2S and its physiological importance have been realized. Abnormal metabolism and functions of H2S contribute to or participate in the pathogenesis of many diseases. This article reviews recent discoveries on the roles of H2S in the regulation of cell proliferation and apoptosis. The molecular mechanisms for the cellular effects of H2S are also recapitulated, including changes in mitogen-activated protein kinase, cell cycle-related kinase, cell death-related gene and ion channels. A better understanding of H2S-regualted cell growth or death will pave way for future design of novel pharmacological and therapeutic interventions for various diseases.

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