Peripheral benzodiazepine receptor agonist Ro5-4864 inhibits mitochondrial permeability transition in rat heart

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LI Jing-Yuan()
WANG Jun-Ke()
ZENG Yin-Ming()
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Volume 59, Issue 01, 2007
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  • [1]Crompton M.The mitochondrial permeability transition pore and its role in cell death.Biochem J 1999; 341:233-249.
  • [2]Halestrap AP,Clarke SJ,Javadov SA.Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection.Cardiovasc Res 2004; 61:372-385.
  • [3]McEnery MW,Snowman AM,Trifiletti RR,Snyder SH.Isolation of the mitochondrial benzodiazepine receptor:association with the voltage-dependent anion channel and the adenine nucleotide carrier.Proc Natl Acad Sci USA 1992; 89:3170-3174.
  • [4]Vin V,Leducq N,Bono F,Herbert JM.Binding characteristics of SSR180575,a potent and selective peripheral benzodiazepine ligand.Biochem Biophys Res Commun 2003; 310:785-790.
  • [5]Clarke SJ,McStay GP,Halestrap AP.Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilinD at a different site from cyclosporin A.J Biol Chem 2002;277:34793-34799.
  • [6]Di Lisa F,Menabo R,Canton M,Barile M,Bemardi P.Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.J Biol Chem 2001; 276:2571-2575.
  • [7]Troyan MB,Gilman VR,Gay CV.Mitochondrial membrane potential changes in osteoblasts treated with parathyroid hormone and estradiol.Exp Cell Res 1997; 233:274-280.
  • [8]Bernardi P,Petronilli V.The permeability transition pore as a mitochondrial calcium release channel:a critical appraisal.J Bioenerg Biomembr 1996; 28:131-138.
  • [9]Schild L,Keilhoff G,Augustin W,Reiser G,Striggow F.Dis tinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria.FASEB J 2001; 15:565-567.
  • [10]Halestrap AP,McStay GP,Clarke SJ.The permeability transition pore complex:another view.Biochimie 2002; 84:153166.
  • [11]Hausenloy DJ,Yellon DM.The mitochondrial permeability transition pore:its fundamental role in mediating cell death during ischaemia and reperfusion.J Mol Cell Cardiol 2003;35:339-341.
  • [12]Papadopoulos V.Peripheral-type benzodiazepine/diazepam binding inhibitor receptor:biological role in steroidogenic cell function.Endocr Rev 1993; 14:222-240.
  • [13]Le Fur G,Vaucher N,Perrier ML,Flamier A,Benavides J,Renault C,Dubroeucq MC,Gueremy C,Uzan A.Differentiation between two ligands for peripheral benzodiazepine binding sites,[3H]RO5-4864 and[3H]PK 11195,by thermodynamic studies.Life Sci 1983; 33:449-457.
  • [14]Martini N,Preckel B,Thamer V,Schlack W.Can isoflurane mimic ischaemic preconditioning in isolated rat heart? Br J Anaesth 2001; 86:269-271.
  • [15]Basso E,Fante L,Fowlkes J,Petronilli V,Forte MA,Bernardi P.Properties of the permeability transition pore in mitochondria devoid of cyclophilin D.J Biol Chem 2005; 280:18558-18561.
  • [16]Bono F,Lamarche I,Prabonnaud V,Le Fur G,Herbert JM.Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities.Biochem Biophys Res Commun 1999;265:457-461.
  • [17]Kletsas D,Li W,Han Z,Papadopoulos V.Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation:role of ERK,cJun and ligand-activated PBR-independent pathways.Biochem Pharmacol 2004; 67:1927-1932.
  • [18]Almeida RD,Manadas BJ,Carvalho AP,Duarte CB.Intracellular signaling mechanisms in photodynamic therapy.Biochim Biophys Acta 2004; 1704:59-86.
  • [19]Leducq N,Bono F,Sulpice T,Vin V,Janiak P,Fur GL,O'Connor SE,Herbert JM.Role of peripheral benzodiazepine receptors in mitochondrial,cellular,and cardiac damage induced by oxidative stress and ischemia-reperfusion.J Pharmacol Exp Ther 2003; 306:828-837.
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