Forced running enhances neurogenesis in the hippocampal dentate gyrus of adult rats and improves learning ability
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2006.05.003
- Key Word:
- 海马;神经发生;齿状回;跑步;5-溴-2-脱氧尿苷;免疫组织化学;迷宫学习;大鼠;hippocampus;neurogenesis;dentate gyrus;running;5-bromo-2-deoxyuridine;immunohistochemistry;maze learning;rats
Abstract： To investigate the effect of forced running in motor-driven wheel on neurogenesis in the hippocampal dentate gyrus (DG)of adult rats, 5-bromo-2-deoxyuridine (BrdU), a thymidine analog was applied to mark cell proliferation. Neuroepthelial stem cell protein (nestin) expression was used to identify neural stem/precursor cells. The BrdU- and nestin-positive cells were examined by immunohistochemical technique. The ability of learning was evaluated by Y-maze test to explore the functional role of the newborn cells in the DG after forced running. It was found that the number of BrdU- and nestin-positive cells in the DG in running groups was significantly increased compared to that in the control group (P＜0.05). The effect of forced running on neurogenesis was intensitydependent. In addition, an improvement of learning ability in Y-maze test was observed after forced running. These findings suggest that forced running in motor-driven wheel could enhance neurogenesis in the hippocampal DG of adult rats and improve learning ability.
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