Postsynaptic calcium pathway contributes to synaptic plasticity between retinal cones and luminosity-type horizontal cells

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HUANG Shi-Yong()
HU Jian-Feng()
GONG Hai-Qing()
LIANG Pei-Ji()
Journal Title:
Volume 58, Issue 05, 2006
Key Word:
AMPA;calcium;neuronal plasticity;retina;ryanodine receptor/calcium release channel

Abstract: It was previously found that the efficacy of synaptic transmission between retinal cone systems and luminosity-type horizontal cells (LHCs) was activity-dependent. Repetitive activation of red-cone pathway increased the LHC's hyperpolarizing response to red light, and the response enhancement was reversible. In this study, intracellular recording and pharmacological method were applied to investigate the mechanism(s) underlying red-flickering-induced response enhancement. Lowering intracellular Ca2+ in the LHC by intracellular injection of Ca2+ chelator EGTA prevented the development of red-flickering-induced response enhancement,which implicates the importance of postsynaptic calcium signal. The response enhancement could also be eliminated by a potent antagonist of Ca2+-permeable AMPA receptor (CP-AMPAR), which suggests the possibility that Ca2+ influx via glutamate-gated calcium channels is related to the changes of [Ca2+]i. Furthermore, the administration of ryanodine or caffeine also attenuated the phenomenon, which gives evidence that the local calcium signal caused by intracellular calcium-induced calcium release (CICR) may be involved. Taken together, our data implicate that postsynaptic CICR and CP-AMPAR are related to the activity-dependent response enhancement.

  • [1]Yang XL (杨雄里).Cone input signals to L-type external horizontal cells of the cyprinid retina.Acta Physiol Sin (生理学报)1985; 37(4):307-315 (Chinese,English abstract).
  • [2]Akopian A,McReynolds J,Weiler R.Short-term potentiation of off-responses in turtle horizontal cells.Brain Res 1991; 546(1):132-138.
  • [3]Fahrenfort I,Habets RL,Spekreijse H,Kamermans M.Intrinsic cone adaptation modulates feedback efficiency from horizontal cells to cones.J Gen Physiol 1999; 114(4):511-524.
  • [4]Hu JF,Liu Y,Liang PJ.Stimulus pattern related plasticity of synapses between cones and horizontal cells in carp retina.Brain Res 2000; 857(1-2):321-326.
  • [5]Malyshev AY,Balaban PM.Synaptic facilitation in Helix neurons depends upon postsynaptic calcium and nitric oxide.Neurosci Lett 1999; 261(1-2):65-68.
  • [6]Nishiyama M,Hong K,Mikoshiba K,Poo MM,Kato K.Calcium stores regulate the polarity and input specificity of synaptic modification.Nature 2000; 408(6812):584-588.
  • [7]Okada T,Schultz K,Geurtz W,Hart H,Weiler R.AMPA-preferring receptors with high Ca2+ permeability mediate dendritic plasticity of retinal horizontal cells.Eur J Neurosci 1999;11(3):1085-1095.
  • [8]Lu T,Shen Y,Yang XL.Desensitization of AMPA receptors on horizontal cells isolated from crucian carp retina.Neurosci Res 1998; 31(2):123-135.
  • [9]Huang SY,Liang PJ.Ca2+-permeable and Ca2+-impermeable AMPA receptors coexist on horizontal cells.Neuro Report 2005;16(3):263-266.
  • [10]Hollmann M,Heinemann S.Cloned glutamate receptors.Annu Rev Neurosci 1994; 17:31-108.
  • [11]Hayashida Y,Yagi T,Yasui S.Ca2+ regulation by the Na+-Ca2+ exchanger in retinal horizontal cells depolarized by L-glutamate.Neurosci Res 1998; 31(3):189-199.
  • [12]Huang SY,Liu Y,Liang PJ.Role of Ca2+ store in AMPA-triggered Ca2+ dynamics in retinal horizontal cells.Neuroreport 2004; 15(15):2311-2315.
  • [13]Linn CL,Gafka AC.Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retina.J Physiol 2001; 535(Pt 1):47-63.
  • [14]Berridge MJ.Neuronal calcium signaling.Neuron 1998; 21(1):13-26.
  • [15]Rose CR,Konnerth A.Stores not just for storage:intracellular calcium release and synaptic plasticity.Neuron 2001; 31 (4):519-522.
  • [16]Linn CP,Christensen BN.Excitatory amino acid regulation of intracellular Ca2+ in isolated catfish cone horizontal cells measured under voltage-and concentration-clamp conditions.J Neurosci 1992; 12(6):2156-2164.
  • [17]Liang PJ.Interaction of cone signals on L-type horizontal cell in carp retina:experiments and modeling.Acta Physiol Sin (生理学报) 1999; 51(4):377-385.
  • [18]Blaschke M,Keller BU,Rivosecchi R,Hollmann M,Heinemann S,Konnerth A.A single amino acid determines the subunit-specific spider toxin block of o-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.Proc Natl Acad Sci USA1993; 90(14):6528-6532.
  • [19]Iino M,Koike M,Isa T,Ozawa S.Voltage-dependent blockage of Ca2+-permeable AMPA receptors by joro spider toxin in cultured rat hippocampal neurones.J Physiol 1996; 496 (Pt 2):431-437.
  • [20]Bezprozvanny I,Watras J,Ehrlich BE.Bell-shaped calcium-response curves of Ins(1,4,5)P3-and calcium-gated channels from endoplasmic reticulum of cerebellum.Nature 1991; 351 (6329):751-754.
  • [21]McPherson PS,Kim YK,Valdivia H,Knudson CM,Takekura H,Franzini-Armstrong C,Coronado R,Campbell KP.The brain ryanodine receptor:a caffeine-sensitive calcium release channel.Neuron 1991; 7(1):17-25.
  • [22]Hayashida Y,Yagi T.On the interaction between voltage-gated conductances and Ca2+ regulation mechanisms in retinal horizontal cells.J Neurophysiol 2002; 87(1):172-182.
  • [23]Denk W,Detwiler PB.Optical recording of light-evoked calcium signals in the functionally intact retina.Proc Natl Acad Sci USA 1999; 96(12):7035-7040.
  • [24]Okada T,Weiler R.Multirecording of Ca2+ signals from inner retinal neurons evoked by light stimulation of photoreceptors.Vision Res 2000; 40(15):1947-1954.
  • [25]Wang JH,Kelly PT.Regulation of synaptic facilitation by postsynaptic Ca2+/CaM pathways in hippocampal CA 1 neurons.J Neurophysiol 1996; 76(1):276-286.
  • [26]Berridge MJ.Elementary and global aspects of calcium signalling.J Physiol 1997; 499 (Pt 2):291-306.
  • [27]Ghosh A,Greenberg ME.Calcium signaling in neurons:molecular mechanisms and cellular consequences.Science 1995; 268(5208):239-247.
  • [28]Friel DD,Tsien RW.A caffeine-and ryanodine-sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on[Ca2+]i.J Physiol 1992; 450:217-246.
  • [29]Usachev YM,Thayer SA.All-or-none Ca release from intracellular stores triggered by Ca2+ influx through voltage-gated Ca2+channels in rat sensory neurons.J Neurosci 1997; 17 (19):7404-7414.
  • [30]Krizaj D,Bao JX,Schmitz Y,Witkovsky P,Copenhagen DR.Caffeine-sensitive calcium stores regulate synaptic transmission from retinal rod photoreceptors.J Neurosci 1999; 19(17):7249-7261.
  • [31]Jin X,Hu JF,Liang PJ.Possible mechanism of flicking-induced short-term plasticity in retinal cone-LHC synapse:a computational study.Biol Cybern 2004; 90(5):360-367.
  • [32]Akopian A,Witkovsky P.Intracellular calcium reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells.J Physio12001; 532(Pt 1):43-53.
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