Postsynaptic calcium pathway contributes to synaptic plasticity between retinal cones and luminosity-type horizontal cells
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2006.05.002
- Key Word:
- AMPA;钙离子;神经元可塑性;视网膜;ryanodine受体/钙释放通道;AMPA;calcium;neuronal plasticity;retina;ryanodine receptor/calcium release channel
Abstract： It was previously found that the efficacy of synaptic transmission between retinal cone systems and luminosity-type horizontal cells (LHCs) was activity-dependent. Repetitive activation of red-cone pathway increased the LHC's hyperpolarizing response to red light, and the response enhancement was reversible. In this study, intracellular recording and pharmacological method were applied to investigate the mechanism(s) underlying red-flickering-induced response enhancement. Lowering intracellular Ca2+ in the LHC by intracellular injection of Ca2+ chelator EGTA prevented the development of red-flickering-induced response enhancement,which implicates the importance of postsynaptic calcium signal. The response enhancement could also be eliminated by a potent antagonist of Ca2+-permeable AMPA receptor (CP-AMPAR), which suggests the possibility that Ca2+ influx via glutamate-gated calcium channels is related to the changes of [Ca2+]i. Furthermore, the administration of ryanodine or caffeine also attenuated the phenomenon, which gives evidence that the local calcium signal caused by intracellular calcium-induced calcium release (CICR) may be involved. Taken together, our data implicate that postsynaptic CICR and CP-AMPAR are related to the activity-dependent response enhancement.
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