Oligomeric interaction between ryanodine receptors: potential role in Ca2+ release
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2006.04.002
- Key Word:
- ryanodine受体;二维晶格排列;受体问相互作用;耦联门控模型;动态耦联模型;ryanodine receptor,2-D array;RyR-RyR interaction;coupled gating;dynamic coupling
Abstract： Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca2+ release is discussed.
- [1]K E, Loesser,L, Castellani,C, Franzini-Armstrong.Dispositions of junctional feet in muscles of invertebrates.[J].1992,13(2).
- [2]D, Bray,M D, Levin,C J, Morton-Firth.Receptor clustering as a cellular mechanism to control sensitivity.[J].1998,393(6680).
- [3]ClaraFranzini-Armstrong,JohnW.Kish.Alternate disposition of tetrads in peripheral couplings of skeletal muscle[J].1995,16(3).
- [4]Donald M, Bers.Cardiac excitation-contraction coupling.[J].2002,415(6868).
- [5]Copello JA,Fill M.Ryanodine receptor calcium release channels.[J].2002,82(4).
- [6]Xiao-Fang Hu,Xin Liang,Ke-Ying Chen,etc.Modulation of the Oligomerization of Isolated Ryanodine Receptors by their Functional States[J].2005,89(3).
- [7]G, Meissner.Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors.[J].1994,56.
- [8]Duke TA,Bray D.Heightened sensitivity of a lattice of membrane receptors.[J].1999,96(18).
- [9]S O, Marx,K, Ondrias,A R, Marks.Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors)[J].1998,281(5378).
- [10]Lamb GD.Excitation-contraction coupling in skeletal muscle: comparisons with cardiac muscle.[J].2000,27(3).
- [11]C, Franzini-Armstrong.The sarcoplasmic reticulum and the control of muscle contraction.[J].1999,13 Suppl 2.
- [12]Hu, X. F.,Liang, X.,Chen, K. Y.,etc.Depletion of FKBP does not affect the interaction between isolated ryanodine receptors[J].2005,336(1).
- [13]D.G. Ferguson,C. Franzini-Armstrong,L. Castellani,etc.Ordered arrays of Ca2+-ATPase on the cytoplasmic surface of isolated sarcoplasmic reticulum[J].1985,48(4).
- [14]Eric A, Sobie,Keith W, Dilly,Jader, dos Santos Cruz,etc.Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.[J].2002,83(1).
- [15]Wang R,Wayne Chen SR,Wagenknecht T,etc.Location of Divergent Region 2 on the Three-dimensional Structure of Cardiac Muscle Ryanodine Receptor/Calcium Release Channel.[J].2004,338(3).
- [16]E, Ríos,G, Pizarro.Voltage sensor of excitation-contraction coupling in skeletal muscle.[J].1991,71(3).
- [17]Hu J,Chen KY,Xu YH,etc.Modulation of the interactions of isolated ryanodine receptors of rabbit skeletal muscle by Na+ and K+.[J].2003,42(18).
- [18]J R, Maddock,L, Shapiro.Polar location of the chemoreceptor complex in the Escherichia coli cell.[J].1993,259(5102).
- [19]Lai FA,Yin CC.Intrinsic lattice formation by the ryanodine receptor calcium-release channel.[J].2000,2(9).
- [20]Lai FA,Blayney LM,Yin CC.Physical coupling between ryanodine receptor-calcium release channels[J].2005,349(3).
- [21]Zissimopoulos S.,Lai FA.,Ralph E.,etc.Ryanodine receptor oligomeric interaction - Identification of a putative binding region[J].2004,279(15).
- [22]Wang SQ.,Cheng HP.,Rios E.,etc.The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells[J].2004,101(11).
- [23]I.I. Serysheva,M. Schatz,M. van Heel,etc.Structure of the Skeletal Muscle Calcium Release Channel Activated with Ca2+ and AMP-PCP[J].1999,77(4).
- [24]C, Franzini-Armstrong,F, Protasi,V, Ramesh.Shape, size, and distribution of Ca(2+) release units and couplons in skeletal and cardiac muscles.[J].1999,77(3).