Oligomeric interaction between ryanodine receptors: potential role in Ca2+ release

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Author:
HU Xiao-Fang()
ZHU Pei-Hong()
HU Jun()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 58, Issue 04, 2006
DOI:
Key Word:
ryanodine receptor, 2-D array;RyR-RyR interaction;coupled gating;dynamic coupling

Abstract: Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca2+ release is discussed.

  • [1]Maddock JR,Shapiro L.Polar location of the chemoreceptor complex in the Escherichia coli cell.Science 1993; 259:1717-1723.
  • [2]Ferguson DG,Franzini-Armstrong C,Castellani L,Hardwicke PM,Kenney LJ.Ordered arrays of Ca2+-ATPase on the cytoplasmic surface of isolated sarcoplasmic reticulum.Biophys J 1985; 48(4):597-605.
  • [3]Bray D,Levin MD,Morton-Firth CJ.Receptor clustering as a cellular mechanism to control sensitivity.Nature 1998; 393:85-88.
  • [4]Duke TA,Bray D.Heightened sensitivity of a lattice of membrane receptors.Proc Natl Acad Sci USA 1999; 96:10104-10108.
  • [5]Rios E,Pizarro G.Voltage sensor of excitation-contraction coupling in skeletal muscle.Physiol Rev 1991; 71(3):849-908.
  • [6]Meissner G.Ryanodine receptor/Ca2+ release channels and their regulation by endogenous effectors.Annu Rev Physiol 1994; 56:485-508.
  • [7]Lamb GD.Excitation-contraction coupling in skeletal muscle:comparisons with cardiac muscle.Clin Exp Pharmacol Physiol 2000; 27(3):216-224.
  • [8]Fill M,Copello JA.Ryanodine receptor calcium release channels.Physiol Rev 2002; 82:893-922.
  • [9]Bers DM.Cardiac excitation-contraction coupling.Nature 2002;415:198-205.
  • [10]Franzini-Armstrong C,Kish J.Alternate disposition of tetrads in peripheral couplings of skeletal muscle.J Mus Res Cell Motil 1995; 16:319-324.
  • [11]Franzini-Armstrong C.The sarcoplasmic reticulum and the control of muscle contraction.FASEB J 1999; 13:S266-S270.
  • [12]Franzini-Armstrong C,Protasi F,Ramesh V.Shape,size,and distribution of Ca2+ release units and couplons in skeletal and cardiac muscles.Biophys J 1999; 77(3):1528-1539.
  • [13]Loesser KE,Castellani L,Franzini-Armstrong C.Dispositions of junctional feet in muscles of invertebrates.J Mus Res Cell Motil 1992; 13:161-173.
  • [14]Yin CC,Lai FA.Intrinsic lattice formation by the ryanodine receptor calcium-release channel.Nat Cell Biol 2000; 2:669-671.
  • [15]Yin CC,Blayney LM,Lai FA.Physical coupling between ryanodine receptor-calcium release channels.J Mol Biol 2005;349(3):538-546.
  • [16]Liu Z,Zhang J,Wang R,Chen Wayne SR,Wagenknecht T.Location of divergent region 2 on the three-dimensional structure of cardiac muscle ryanodine receptor/calcium release channel.J Mol Biol 2004; 338:533-545.
  • [17]Blayney LM,Zissimopoulos S,Ralph E,Abbot E,Matthews L,Lai FA.Ryanodine receptor oligomeric interaction:identification of a putative binding region.J Biol Chem 2004; 279:14639-14648.
  • [18]Wang SQ,Stern MD,RíosE,Cheng H.The quantal nature of Ca2+sparks and in situ operation of the ryanodine receptor array in cardiac cells.Proc Natl Acad Sci USA 2004; 101:3979-3984.
  • [19]Marx SO,Ondrias K,Marks AR.Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors).Science 1998; 281:818-821.
  • [20]Marx SO,Gaburjakova J,Gaburjakova M,Henrikson C,Ondrias K,Marks AR.Coupled gating between cardiac cacium release channels (ryanodine receptors).Circ Res 2001; 88:1151-1158.
  • [21]Stern MD,Song LS,Cheng H,Sham JS,Yang HT,Boheler KR,Rios E.Local control models of cardiac excitation-contraction coupling.A possible role for allosteric interactions between ryanodine receptors.J Gen Physiol 1999; 113(3):469-489.
  • [22]Sobie EA,Dilly KW,dos Santos Cruz J,Lederer WJ,Jafri MS.Termination of cardiac Ca2+ sparks:an investigative mathematical model of calcium-induced calcium release.Biophys J 2002; 83(1):59-78.Erratum in:Biophys J 2004; 86(5):3329.
  • [23]Schatz M,Heel M,Chiu W,Hamilton SL.Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMPPCP.Biophys J 1999; 77:1936-1944.
  • [24]Hu XF,Chen KY,Xia R,Xu Y,SunJL,Hu J,ZhuPH.Modulation of the interactions of isolated ryanodine receptors of rabbit skeletal muscle by Na+ and K+.Biochemisty 2003; 42(18):5515-5521.
  • [25]Hu XF,Liang X,Chen KY,Xie H,Xu Y,Zhu PH,Hu J.Modulation of the oligomerization of isolated ryanodine receptors by their functional states.Biophys J 2005; 89(3):1692-1699.
  • [26]Hu XF,Liang X,Chen KY,Zhu PH,Hu J.Depletion of FKBP does not affect the interaction between isolated ryanodine receptors.Biochem Biophys Res Commun 2005; 336(1):128-133.
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