Simvastatin inhibits hypertension-induced cardiac hypertrophy in rats through activation of heme oxygenase-1/carbon monoxide pathway

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Author:
YAO Hai-Mu()
WU Xue-Si()
ZHANG Jing()
GENG Bin()
TANG Chao-Shu()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 58, Issue 02, 2006
DOI:
Key Word:

Abstract:

  • [1]Glennon PE,Sugden PH,Poole-Wilson PA.Cellular mechanisms of cardiac hypertrophy.Br Heart J 1995; 73:496-499.
  • [2]LaRosa JC,Smith GD.Statins and risk of coronary heart disease.JAMA 2000; 283:2935-2936.
  • [3]Chen MS,Xu FP,Wang YZ,Zhang GP,Yi Q,Zhang HQ,Luo JD.Statins initiated after hypertrophy inhibit oxidative stress and prevent heart failure in rats with aortic stenosis.J Mol Cell Cardiol 2004; 37:889-896.
  • [4]Akamatsu Y,Haga M,Tyagi S,Yamashita K,Graca-Souza AV,Ollinger R,Czismadia E,May GA,Ifedigbo E,Otterbin LE,Bach FH,Soares MP.Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury.FASEB J 2004; 18:771-772.
  • [5]Hu CM,Chen YH,Chiang MT,Chau LY.Heme oxygenase-1 inhibits angiotensin Ⅱ-induced cardiac hypertrophy in vitro and in vivo.Circulation 2004; 110:309-316.
  • [6]Grosser N,Erdmann K,Hemmerle A,Berndt G,Hinkelmann U,Smith G,Schroder H.Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1.Biochem Biophys Res Commun 2004; 325:871-876.
  • [7]Lee TSM,Chang CC,Zhu Y,Shyy JY.Simvastatin induces heme oxygenase-1.A novel mechanism of vessel protection.Circulation 2004; 110:1296-1302.
  • [8]Morita T,Kourembanas S.Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.J Clin Invest 1995; 96:2676-2682.
  • [9]Simpson P,Savion S.Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells.Cross-striations,ultrastructure,and chronotropic response to isoproterenol.Circ Res 1982; 50:101-116.
  • [10]Chalmers AH.Simple,sensitive measurement of carbon monoxide in plasma.Clin Chem 1991; 37:1442-1445.
  • [11]Shepherd J,Blauw GJ,Murphy MB,Bollen EL,Buckey BM,Cobbe SM,Ford I,Gaw A,Hyland M,Jukema JW,Kamper AM,Macfarlane PW,Meinders AE,Norrie J,Packard C J,Perry IJ,Stott DJ,Sweeney B J,Twomey C,Westendorp RG.Pravastatin in elderly individuals at risk of vascular disease (PROSPER):a randomised controlled trial.Lancet 2002; 360:1623-1630.
  • [12]Wierzbicki AS,Poston R,Ferro A.The lipid and non-lipid effect of statins.Pharmacol Ther 2003; 99:95-112.
  • [13]Maines MD,Ibranhim NG,Kapps A.Solubilization and parrial purification of heme oxygenase from rat liver.J Bio Chem 1997; 252:5900-5903.
  • [14]Johnson RA,Colombari E,Colombari DS,Lavesa M,Talman WT,Nasuletti A.Role of endogenous carbon monoxide in central regulation of arterial pressure.Hypertension1997; 30:962-967.
  • [15]Tongers J,Fiedler B,Konig D,Kempf T,Klein G,Heineke J,Kraft T,Gambaryan S,Lohmann SM,Drexler H,Wollert KC.Heme oxygenase-1 inhibition of MAP kinases,calcineurin/NFAT signaling,and hypertrophy in cardiac myocytes.Cardiovasc Res 2004; 63:545-552.
  • [16]Qi YF (齐永芬),Shi YR,Bu DF,Jiang HF,Gao L,Pang YZ,Tang CS.Changes in adrenomedullin and receptor activitymodifying protein 2 mRNA in myocardium and vessels during L-NNA-induced hypertension in rats.Acta Physiol Sin (生理学报) 2002; 54:337-341 (Chinese,English abstract).
  • [17]Liao JK.Statin therapy for cardiac hypertrophy and heart failure.J Invest Med 2004; 52:248-253.
  • [18]Jiang J,Roman RJ.Lovastatin prevents development of hypertension in spontaneously hypertensive rats.Hypertension 1997; 30:968-974.
  • [19]Ledingham JM,Laverty R.Effect of simvastatin given alone and in combination with valsartan or enalapril on blood pressure and the structure of mesenteric resistance arteries and the basilar artery in the genetically hypertensive rat model.Clin Exp Pharmacol Physiol 2005; 32:76-85.
  • [20]Ichihara A,Hayashi M,Koura Y.Long-term effects of statins on arterial pressure and stiffness of hypertensives.J Hum Hypertens 2005; 19:103-109.
  • [21]Susic D,Varagic J,Ahn J,Slama M,Frohlich ED.Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models.J Am Coll Cardiol 2003; 42:1091-1097.
  • [22]Christodoulides N,Durante W,Kroll MH,Schafer AI.Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase stimulatory carbon monoxide.Circulation 1995; 91:2306-2309.
  • [23]Foresti R,Goatly H,Green C J,Motterlini R.Role of heme oxygenase-1 in hypoxia reoxygenation:requirement of substrate heme to promote cardioprotection.Am J Physiol Heart Circ Physiol 2001; 281:H1976-H1984.
  • [24]Grosser N,Hemmerle A,Berndt G,Erdmann K,Hinkelmann U,Schurgerc S,Wijayanti N,Immenschuh S,Schroder H.The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells.Free Radic Biol Med 2004;37:2064-2071.
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