Cl- channels: what role do they play in mammalian heart?

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ZHOU Shi-Sheng()
Journal Title:
Volume 58, Issue 02, 2006
Key Word:
Cl- channels;cation channels;electrophysiology, cardiac myocyte, heart

Abstract: Cl- channel has been identified in heart over more than a decade. It is now known that Cl- channel is a super-family. The potentially important roles of cardiac Cl- channels have been emerging. Cardiac Cl- channels may play multifunctional roles in both physiological and pathophysiological conditions. Since the existence and distribution of cardiac Cl- channels vary with species and cardiac tissues, and blockade of Cl- channel with putative Cl- channel blockers or Cl- substitution has profound influence on cardiac electrical properties, it appears that the main role of cardiac Cl- channels may be to modulate cation channels or provide an ionic environment suitable for the activities of cation channels. So, to investigate the relationship between Cl- channels and cation channels may be of physiological and pathophysiological significance.

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