You Position: Home > Paper

Hypoxia inducible factor-1α and leukemic cell differentiation

( views:148, downloads:34 )
Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
1
DOI:
10.3321/j.issn:0371-0874.2006.01.002
Key Word:
白血病;低氧诱导因子-1;CCAAT/增强子结合蛋白;三氧化二砷;细胞分化;leukemia;hypoxia inducible factor-1;CCAAT/enhancer-binding protein-α;arsenic trioxide;differentiation

Abstract: Arsenic trioxide (As2O3, ATO) is a recently developed drug for the effective treatment of acute promyelocytic leukemia (APL). Experimental studies showed that in vitro differentiation-inducing ability on APL cells of this drug is not significant compared with its in vivo activity. We unexpectedly found recently that hypoxia-mimetic agents and moderate real hypoxia triggered acute myeloid leukemic cells to undergo differentiation. Furthermore, intermittent hypoxia significantly prolonged the survival of the transplanted leukemic mice with inhibition of infiltration and induction of differentiation of leukemic cells. In the following works,molecular mechanisms of hypoxia-induced differentiation were investigated and some interesting results have been obtained. This review will shortly summarize the related progresses and discuss the questions remained to be further investigated.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn