You Position: Home > Paper
Expression of man, a formin homology domain-containing gene in the mouse limb
( views:146, downloads:8 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2005.04.004
- Key Word:
- man基因;formin蛋白;formin同源功能区;FH1和FH2;鼠四肢;细胞分裂;表达克隆;man;formin;FH1;FH2;mouse limb;cytokinesis;expression cloning
Abstract： Formin defines a family of structurally related proteins that have two formin homology domains (FH1 and FH2). Various mutations in the formin locus result in limb deformity, suggesting that these genes play indispensable roles in the limb development.Here we report the isolation of a novel cDNA, man, from the mouse limb, which contains two conserved FH1 and FH2 domains. Its expression is described and possible functional significance is discussed.
- [1]K, Tanaka.Formin family proteins in cytoskeletal control.[J].2000,267(2).
- [2]McMahon J. A.,Takada S.,Zimmerman L. B.,etc.Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and\u00a0somite[J].1998.
- [3]Mariani FV.,Liu KJ.,Grammer TC.,etc.Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function[J].2000,228(2).
- [4]Kovar DR,Pollard TD,Wu JQ.Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast[J].2005,16(5).
- [5]Brunet,LJ,McMahon,JA,McMahon,AP,etc.Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton (see comments)[J].1998,280(5368).
- [6]Zeller R,James D,Fumagalli S,etc.Molecular interaction between limb deformity proteins (formins) and Src family kinases.[J].1996,271(52).
- [7]D H, Castrillon,S A, Wasserman.Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene.[J].1994,120(12).
- [8]Watanabe T,Yayoshi Yamamoto-S,Taniuchi I.FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.[J].2000,20(18).
- [9]Niswander L.Limb mutants: what can they tell us about normal limb development?[J].1997,7(4).
- [10]Bershadsky AD,Kozlov MM.Processive capping by formin suggests a force-driven mechanism of actin polymerization.[J].2004,167(6).
- [11]Isabelle Sagot,Saskia K. Klee,David Pellman.Yeast formins regulate cell polarity by controlling the assembly of actin cables[J].2002,4(1).
- [12]H, Peters,A, Neubüser,K, Kratochwil,etc.Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.[J].1998,12.
- [13]Umikawa M.,Hihara T.,Takahashi K. Sasaki T.,etc.Bni1p and Bnr1p - Downstream Targets of the Rho Family Small G-Proteins Which Interact with Profilin and Regulate Actin Cytoskeleton in Saccharomyces Cerevisiae[J].1997,16(10).
- [14]Tominaga T,Sahai E,Chardin P,etc.Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.[J].2000,5(1).
- [15]Westendorf JJ.The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element.[J].2001,276(49).
- [16]M, Kozak.An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.[J].1987,15(20).
- [17]M.Kozak.Interpreting cDNA sequences: Some insights from studies on translation[J].1996,7(8).
- [18]Feierbach B,Chang F.Roles of the fission yeast formin for3p in cell polarity, actin cable formation and symmetric cell division[J].2001,11(21).
- [19]Ridgeway AG,Wilton S,Skerjanc IS.Myocyte enhancer factor 2C and myogenin up-regulate each other's expression and induce the development of skeletal muscle in P19 cells.[J].2000,275(1).
- [20]Watanabe N.,Reid T.,Ishizaki T.,etc.P140mdia, a Mammalian Homolog of Drosophila Diaphanous, is a Target Protein for Rho Small Gtpase and is a Ligand for Profilin[J].1997,16(11).
- [21]R. Zeller,A. G. Haramis,A. Zuniga,etc.Formin defines a large family of morphoregulatory genes and functions in establishment of the polarising region[J].1999,296(1).