Expression of man, a formin homology domain-containing gene in the mouse limb

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Author:
CUI Yan-Zhen()
PENG Yi-Feng()
TIAN Qi()
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
Volume 57, Issue 04, 2005
DOI:
Key Word:
man;formin;FH1;FH2;mouse limb;cytokinesis;expression cloning

Abstract: Formin defines a family of structurally related proteins that have two formin homology domains (FH1 and FH2). Various mutations in the formin locus result in limb deformity, suggesting that these genes play indispensable roles in the limb development.Here we report the isolation of a novel cDNA, man, from the mouse limb, which contains two conserved FH1 and FH2 domains. Its expression is described and possible functional significance is discussed.

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