Transcription factor Egr-1 is required for long-term fear memory and anxiety

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Shanelle W.Ko()
AO Hu-Shan()
Amelia Gallitano-Mendel()
QIU Chang-Shen()
WEI Feng()
Jeffrey Milbrandt()
ZHUO Min()
Journal Title:
Volume 57, Issue 04, 2005
Key Word:
Egr-1;long-term potentiation;fear memory;amygdala;auditory cortex

Abstract: The zinc finger transcription factor Egr-1 is critical for coupling extracellular signals to changes in cellular gene expression.In the hippocampus and amygdala, two major central regions for memory formation and storage, Egr-1 is up-regulated by long-term potentiation (LTP) and learning paradigms. Using Egr-1 knockout mice, we showed that Egr-1 was selectively required for late auditory fear memory while short term, trace and contextual memory were not affected. Additionally, synaptic potentiation induced by theta burst stimulation in the amygdala and auditory cortex was significantly reduced or blocked in Egr-1 knockout mice. Our study suggests that the transcription factor Egr-1 plays a selective role in late auditory fear memory.

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