Role of the central interleukin-1 in stress responses

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ZHENG Rui-Mao()
ZHU Shi-Gong()
Journal Title:
Volume 57, Issue 04, 2005
Key Word:
interleukin-1;central nervous system;stress

Abstract: The molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory facto r, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-l. This paper reviews some recent findings in the studies of central IL- 1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.

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