Dynamic changes of heme oxygenase-1 protein and mRNA in the brains of rats with experimental allergic encephalomyelitis

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Volume 56, Issue 05, 2004
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  • [1]Emerson MR, LeVine SM. Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response.J Neurochem 2000;75(6): 2555-2562.
  • [2]Liu Y, Zhu B, Luo L, Li P, Paty DW, Cynader MS. Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. Neuroreport 2001; 12(9):1841-1845.
  • [3]Hewett S J, Misko TP, Keeling RM, Behrens MM, Choi DW, Cross AH. Murine encephalitogenic lymphoid cells induce nitric oxide synthase in primary astrocytes. J Neuroimmunol 1996;64(2):201-208.
  • [4]Forge JK, Pedchenko TV, LeVine SM. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 1998;63(25):2271-2284.
  • [5]Pedchenko TV, LeVine SM. Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice. J Neuroimmunol 1998;84(2):188-197.
  • [6]Tan GJ(檀国军),Yang TZ,Zhao XY,Zhou LX,Cao CL,Ma CS. The role of activation of nuclear factor-kappa B of rat brains in the pathogenesis of experimental allergic encephalomyelitis.Acta Physiol Sin(生理学报)2003;55(1):58-64(Chinese, English abstract).
  • [7]Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 1998; 161 (12):6480-6486.
  • [8]Shibahara S, Sato M, Muller RM, Yoshida T. Structural organization of the human heme oxygenase gene and the function of its promoter. Eur J Biochem 1989;179(3):557-563.
  • [9]Galbraith R. Heme oxygenase: who needs it? Proc Soc Exp Biol Med 1999; 222(3):299-305.
  • [10]Wagener FA, Eggert A, Boerman OC, Oyen WJ, Verhofstad A, Abraham NG, Adema G, van Kooyk Y, de Witte T, Figdor CG. Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase. Blood 2001 ;98(6): 1802-1811.
  • [11]McCoubrey WK Jr, Huang TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 1997;247(2):725-732.
  • [12]Terry CM, Clikeman JA, Hoidal JR, Callahan KS. Effect of tumor necrosis factor-alpha and interleukin-1 alpha on heme oxygenase-1 expression in human endothelial cells. Am J Physiol 1998;274(3 Pt 2):H883-H891.
  • [13]Ono S, Zhang ZD, Marton LS, Yamini B, Windmeyer E, Johns L, Kowalczuk A, Lin G, Macdonald RL. Heme oxygenase-1and ferritin are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab 2000;20(7): 1066-1076.
  • [14]Le WD, Xie WJ, Appel SH. Protective role of heme oxygenase1 in oxidative stress-induced neuronal injury. J Neurosci Res 1999;56(6):652-658.
  • [15]Schluesener HJ, Seid K. Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis. J Neuroimmunol2000; 110(1-2): 114-120.
  • [16]Platt JL, Nath KA. Heme oxygenase: protective gene or Trojan horse. Nat Med 1998;4(12): 1364-1365.
  • [17]Zhang FY(张凤蕴),Lu XY,Yu WL,Wang LQ,Wang L,Li DJ.Assay of some kinds of cytokines in experimental allergicencephalomyelitis model. Chin J Neuroimmunol Neurol(中国神经免疫和神经病学杂志)2000;7(1):45-48(Chinese,English abstract).
  • [18]Denk A, Wirth T, Baumann B. NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival. Cytokine Growth Factor Rev 2000;11(4):303-320.
  • [19]Steiner AA, Branco LG. Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway. Am J Physiol Regul Integr Comp Physiol 2001;280(2): R448-R457.
  • [20]Rivest S. Molecular insights on the cerebral innate immune system. Brain Behav Immun 2003;17(1):13-19.
  • [21]Quan N, Stern EL, Whiteside MB, Herkenham M. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol 1999;93(1-2):72-80.
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