Paper - WANFANG MED ONLINE

You Position: Home > Paper

Baroreceptor reflex in heart failure

( views:316, downloads:17 )

Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 3

DOI:: 10.3321/j.issn:0371-0874.2004.03.001

Key Word:: 压力感受器反射;化学感受器反射;心力衰竭;血管紧张素Ⅱ;活性氧;运动训练;baroreceptor reflex;chemoreceptor reflex;heart failure;angiotensin Ⅱ;reactive oxygen species;exercise training

Abstract： Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that: (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin Ⅱ and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

Reference

[1]Raffi R Kaprielian,Emmanuel Dupont,Sassan Hafizi,etc.Angiotensin II Receptor Type 1 mRNA is Upregulated in Atria of Patients with End-stage Heart Failure[J].1997,29(8).
[2]Irving H, Zucker,Rainer U, Pliquett.Novel mechanisms of sympatho-excitation in chronic heart failure.[J].2002,3(1).
[3]Z J, Bosnjak,J P, Kampine.Cardiac sympathetic afferent cell bodies are located in the peripheral nervous system of the cat.[J].1989,64.
[4]S Y, Sun,W, Wang,I H, Zucker,etc.Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure.[J].1999,86.
[5]S, Schaefer.Cardiovascular applications of nuclear magnetic resonance spectroscopy.[J].1989,64(9).
[6]D W, Ferguson,F M, Abboud,A L, Mark.Selective impairment of baroreflex-mediated vasoconstrictor responses in patients with ventricular dysfunction.[J].1984,69.
[7]Chantal Lambert,Yolette Massillon,Sylvain Meloche.Upregulation of Cardiac Angiotensin II AT sub 1 Receptors in Congenital Cardiomyopathic Hamsters[J].1995,77(5).
[8]Murakami H.,Liu J.-L.,Zucker I. H..Angiotensin II Enhances Baroreflex Control of Sympathetic Outflow in Heart Failure[J].1997.
[9]R M, Oren,P J, Roach,H P, Schobel,etc.Sympathetic responses of patients with congestive heart failure to cold pressor stimulus.[J].1991,67(11).
[10]D W, Ferguson,W J, Berg,J S, Sanders.Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: evidence from direct microneurographic recordings.[J].1990,16.
[11]J L, Liu,I H, Zucker.Regulation of sympathetic nerve activity in heart failure: a role for nitric oxide and angiotensin II.[J].1999,84.
[12]Y, Uchida,S, Murao.Potassium-induced excitation of afferent cardiac sympathetic nerve fibers.[J].1974,226(3).
[13]Y, Uchida,S, Murao.Acid-induced excitation of afferent cardiac sympathetic nerve fibers.[J].1975,228.
[14]Rong, Ma,Irving H, Zucker,Wei, Wang.Central gain of the cardiac sympathetic afferent reflex in dogs with heart failure.[J].1997,273(6).
[15]Wong J,Chou L,Reid I A.Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit.[J].1993.
[16]N.-O. Abdon,Niels A. Nielsen.The Localisation of the Cardio-Inhibitory Vagal Effect Caused by Digitalis[J].1938,78(1).
[17]W, Markiewicz,S S, Wu,W W, Parmley,etc.Evaluation of the hereditary Syrian hamster cardiomyopathy by 31P nuclear magnetic resonance spectroscopy: improvement after acute verapamil therapy.[J].1986,59.
[18]Johnson AK,Wei SG,Weiss RM,etc.Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure.[J].2001,281(5).
[19]Junichi Suzuki,Hiroaki Matsubara,Masaya Urakami,etc.Rat Angiotensin II ( Type 1A) Receptor mRNA Regulation and Subtype Expression in Myocardial Growth and Hypertrophy[J].1993,73(3).
[20]W, Wang,R, Ma.Cardiac sympathetic afferent reflexes in heart failure.[J].2000,5(1).
[21]W, Wang,J S, Chen,I H, Zucker.Carotid sinus baroreceptor sensitivity in experimental heart failure.[J].1990,81.
[22]G W, Moe,T P, Stopps,C, Angus,etc.Alterations in serum sodium in relation to atrial natriuretic factor and other neuroendocrine variables in experimental pacing-induced heart failure.[J].1989,13(1).
[23]COVELL J. W.,CHIDSEY C. A.,BRAUNWALD E..Reduction of the Cardiac Response to Postganglionic Sympathetic Nerve Stimulation in Experimental Heart Failure[J].1966.
[24]J S, Sanders,D W, Ferguson.Cardiopulmonary baroreflexes fail to modulate sympathetic responses during isometric exercise in humans: direct evidence from microneurographic studies.[J].1988,12(5).
[25]A J, Minisi,M D, Thames.Activation of cardiac sympathetic afferents during coronary occlusion. Evidence for reflex activation of sympathetic nervous system during transmural myocardial ischemia in the dog.[J].1991,84.
[26]V L, Brooks.Interactions between angiotensin II and the sympathetic nervous system in the the long-term control of arterial pressure.[J].1997,24(1).
[27]L, Vanhees,R, Fagard,P, Lijnen,etc.Influence of physical training on blood pressure, plasma renin, angiotensin and catecholamines in patients with ischaemic heart disease.[J].1984,53(3).
[28]Wang, Wei,Zucker, Irving H..Cardiac sympathetic afferent reflex in dogs with congestive heart failure.[J].1996,40(3).
[29]Matthew C, Zimmerman,Eric, Lazartigues,Julie A, Lang,etc.Superoxide mediates the actions of angiotensin II in the central nervous system.[J].2002,91.
[30]Homcy C J,Vatner S F,Vatner D E.\u03b2-Adrenergic Receptor Regulation in the Heart in Pathophysiologic States: Abnormal Adrenergic Responsiveness in Cardiac Disease[J].1991.
[31]S Y, Sun,W, Wang,I H, Zucker,etc.Enhanced activity of carotid body chemoreceptors in rabbits with heart failure: role of nitric oxide.[J].1999,86.
[32]V J, Dzau,W S, Colucci,G H, Williams,etc.Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure.[J].1980,302.
[33]Tuan Peng Chua,Piotr Ponikowski,Derek Harrington,etc.Clinical Correlates and Prognostic Significance of the Ventilatory Response to Exercise in Chronic Heart Failure[J].1997,29(7).
[34]Piotr Ponikowski,Tuan Peng Chua,Massimo Piepoli,etc.Augmented Peripheral Chemosensitivity as a Potential Input to Baroreflex Impairment and Autonomic Imbalance in Chronic Heart Failure[J].1997,96(8).
[35]H. HJELMQVIST,J. ULLMAN,B. HAMBERGER,etc.Cardiovascular and renal effects of intracerebroventricular angiotensin II in conscious sheep[J].1992,145(1).
[36]J N, Cohn,T B, Levine,M T, Olivari,etc.Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure.[J].1984,311.
[37]Ilaria Nicoletti,Mariantonietta Cicoira,Luisa Zanolla,etc.Skeletal Muscle Abnormalities in Chronic Heart Failure Patients: Relation to Exercise Capacity and Therapeutic Implications[J].2003,9(3).
[38]Clemson B,Gaul L,Gubin S S,etc.Prejunctional angiotensin II receptors. Facilitation of norepinephrine release in the human forearm.[J].1994.
[39]Gabutti A,Spicuzza L,Bernardi L,etc.Slow breathing reduces chemoreflex response to hypoxia and hypercapnia, and increases baroreflex sensitivity.[J].2001,19(12).
[40]M J, Panzenbeck,W, Tan,M A, Hajdu,etc.Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs.[J].1988,63.
[41]B H, Machado.Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats.[J].2001,940.
[42]Timmers HJ,Kaanders JH,Folgering HT,etc.Arterial baroreflex and peripheral chemoreflex function after radiotherapy for laryngeal or pharyngeal cancer.[J].2002,53(5).
[43]J W, Wright,J W, Harding.Regulatory role of brain angiotensins in the control of physiological and behavioral responses.[J].1900,17(3).
[44]M E, Dibner-Dunlap,M D, Thames.Baroreflex control of renal sympathetic nerve activity is preserved in heart failure despite reduced arterial baroreceptor sensitivity.[J].1989,65.
[45]D W, Ferguson,W J, Berg,P J, Roach,etc.Effects of heart failure on baroreflex control of sympathetic neural activity.[J].1992,69(5).
[46]Ferrario C. M.,Dickinson C. J.,McCubbin J. W..Central Vasomotor Stimulation by Angiotensin[J].1970.
[47]G A, Head.Role of AT1 receptors in the central control of sympathetic vasomotor function.[J].1996,23 Suppl 3.
[48]I, Tikkanen,K, Helin,T, Tikkanen,etc.Elevation of plasma atrial natriuretic peptide in rats with chronic heart failure by SCH 39370, a neutral metalloendopeptidase inhibitor.[J].1990,254.
[49]G S, Francis.The relationship of the sympathetic nervous system and the renin-angiotensin system in congestive heart failure.[J].1989,118(3).
[50]Jwo-Sheng Chen,Wei Wang,Thomas Bartholet,etc.Analysis of Baroreflex Control of Heart Rate in Conscious Dogs With Pacing&hyphen; Induced Heart Failure[J].1991,83(1).
[51]J, Staszewska-Woolley,G, Woolley,D, Regoli.Specific receptors for bradykinin-induced cardiac sympathetic chemoreflex in the dog.[J].1988,156(3).
[52]W, Wang,J S, Chen,I H, Zucker.Carotid sinus baroreceptor reflex in dogs with experimental heart failure.[J].1991,68.
[53]T K, Peters,R, Daube,E, Zerbst.Cardiovascular responses to time delays of electrocardiogram-coupled electrical stimulation of carotid sinus nerves in dogs.[J].1988,25(2-3).
[54]Wang, Wei,Schultz, Harold D..Cardiac sympathetic afferent sensitivity is enhanced in heart failure.[J].1999,46(2).
[55]S R, Goldsmith,G S, Francis,A W, Cowley,etc.Increased plasma arginine vasopressin levels in patients with congestive heart failure.[J].1983,1(6).
[56]F G, Spinale,R, Tanaka,F A, Crawford,etc.Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy.[J].1992,85.
[57]P B, Timmermans,P C, Wong,A T, Chiu,etc.Angiotensin II receptors and angiotensin II receptor antagonists.[J].1993,45.
[58]S R, Goldsmith,G J, Hasking,E, Miller.Angiotensin II and sympathetic activity in patients with congestive heart failure.[J].1993,21(5).
[59]Nio Y,Murasawa S,Kanasaki M,etc.Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.[J].1995,95(1).
[60]Marian Brandle,Wei Wang,Irving Zucker.Ventricular Mechanoreflex and Chemoreflex Alterations in Chronic Heart Failure[J].1994,74(2).
[61]M.J.Niebauer,M.J.Holmberg,I.H.Zucker.Aortic baroreceptor characteristics in dogs with chronic high output failure[J].1986,81(2).
[62]Schulz, Harold D.,Wang, Wei.Enhanced responsiveness of cardiac vagal chemosensitive endings to bradykinin in heart failure.[J].1997,42(2).
[63]M D, Thames,T, Kinugawa,M E, Dibner-Dunlap.Reflex sympathoexcitation by cardiac sympathetic afferents during myocardial ischemia. Role of adenosine.[J].1993,87.
[64]C G, Brilla,B, Maisch,K T, Weber.Renin-angiotensin system and myocardial collagen matrix remodeling in hypertensive heart disease: in vivo and in vitro studies on collagen matrix regulation.[J].1993,71(5 Suppl).