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Vasorelaxing effect of idoxifene on human internal mammary arteries
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.2004.01.003
- Key Word:
- 吲哚昔酚(idoxifene);雌激素;人乳内动脉;血管舒张
Abstract： 为了研究idoxifene(吲哚昔酚,一种新型雌激素受体调节剂)对人乳内动脉(humaninternal mammary artery,HIMA)的舒张作用及其机制,采用离体血管灌流的方法,观察idoxifene对完整内皮和去内皮HIMA的舒张作用,以及L-NAME和美蓝(methylene blue,MB)对这一过程的影响,并且和17β雌二醇(17β-estradiol,E2)的舒血管作用进行了比较.实验中观察到保留血管内皮时idoxifene(0.01～10μmo1/L)和JE2(0 1～100μmo1/L)可以剂量依赖性地舒张血管,且血管对idoxifene 的灵敏度比对E2高15倍左右,而去内皮时则无此作用;NO合成酶阻断剂L-NAME和鸟苷酸环化酶(guanylate cyclase,GC)的抑制剂MB使idoxifene舒张HIMA的作用完全消失.上述结果表明:idoxifene能够剂量依赖性地舒张HIMA,而且比E2更有效.idoxifene的这种作用足通过NO-GC-cGMP通路实现的.
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