Electrophysiological effects of capsaicin on guinea pig papillary muscles
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2003.05.003
- Key Word:
- 生理学;辣椒素;动作电位;乳头状肌;physiology;capsaicin;action potential;papillary muscles
Abstract： The cardiac electrophysiological effects of capsaicin (CAP) were examined in guinea pig papillary muscles using intracellular microelectrode technique. The results obtained are as follows: (1) the duration of action potential (APD) in normal papillary muscles was decreased by CAP (30, 60, 120 μmol/L) in a concentration-dependent manner; (2) in partially depolarized papillary muscles, 60 μmol/L CAP not only reduced APD, but also decreased the amplitude of action potential,overshoot and maximal velocity of phase 0 depolarization; (3) pretreatment with L-type Ca2 + channel agonist Bay K8644 (0. 5μmol/L) could completely block the effects of CAP (60 μmol/L); (4) pretreatment with ruthenium red (20μmol/L), a vanilloid receptor (VR) blocker, did not affect the actions of capsaicin on papillary muscles. All these results suggest that the effects of CAP on papillary muscles are likely due to a decrease in calcium influx which is not mediated by VR.
- [1]程岩萍,王义和,程利萍,等.辣椒素对家兔窦房结起搏细胞的电生理效应[J].2003,(8).
- [2]T, Bíró,C, Brodie,S, Modarres,etc.Specific vanilloid responses in C6 rat glioma cells.[J].1998,56.
- [3]Tosaki A,Oroszi G,Nemeth J,etc.Functional and biochemical evidence for capsaicin-induced neural endothelin release in isolated working rat heart.[J].2001,419(2).
- [4]周伏文,李元建,邓汉武.辣椒辣素对大鼠再灌注损伤的心肌早期和延迟保护作用.[J].1999,(10).
- [5]Makoto Suzuki,Gaku Ohki,Toshio Mochizuki,etc.Opening of ligand-gated cation channel families by calpain inhibitors[J].2002,517(1-3).
- [6]M J, Caterina,M A, Schumacher,M, Tominaga,etc.The capsaicin receptor: a heat-activated ion channel in the pain pathway.[J].1997,389.
- [7]T, Bíró,M, Maurer,S, Modarres,etc.Characterization of functional vanilloid receptors expressed by mast cells.[J].1998,91.
- [8]Martins JB,Arnar DO,Lee HC,etc.Electrophysiologic effects of civamide (zucapsaicin) on canine cardiac tissue in vivo and in vitro.[J].1998,32(6).
- [9]H D, Schultz,E E, Ustinova.Capsaicin receptors mediate free radical-induced activation of cardiac afferent endings.[J].1998,38.
- [10]K, Ono,M, Delay,T, Nakajima,etc.Calcitonin gene-related peptide regulates calcium current in heart muscle.[J].1989,340.
- [11]R H, An,R R, He.Electrophysiological effects of m-nisoldipine and nisoldipine on papillary muscles of guinea pig.[J].1990,11(4).
- [12]Verónica Milesi,Alejandro Rebolledo,Alicia Gómez Alvis,etc.Voltage-Activated Sodium Current Is Inhibited by Capsaicin in Rat Atrial Myocytes[J].2001,282(4).
- [13]F, Ledda,S, Amerini,S, Filippi,etc.Cardiovascular effects of capsaicin-sensitive neurons.[J].1993,4.
- [14]Antunes E,Costa SK,Nathan LP,etc.Modulation of coronary flow and cardiomyocyte size by sensory fibers.[J].1999,34(4 Pt.2).
- [15]L.Hernádi,L.Erdélyi,A.Párducz,etc.In vitro capsaicin-induced cytological changes and alteration in calcium distribution in giant serotonergic neurons of the snailHelix pomatia: a light- and electron-microscopic study[J].1995,282(3).
- [16]A. FRANCO-CERECEDA,J. M. LUNDBERG,A. SARIA,etc.Calcitonin gene-related peptide: release by capsaicin and prolongation of the action potential in the guinea-pig heart[J].1988,132(2).
- [17]N A, Castle.Differential inhibition of potassium currents in rat ventricular myocytes by capsaicin.[J].1992,26.
- [18]Rainer Amann,Carlo Alberto Maggi.Ruthenium red as a capsaicin antagonist[J].1991,49(12).