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Bombesin-mediated non-cholinergic late slow excitatory postsynaptic potentials in guinea pig inferior mesenteric ganglion in vitro
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2003.04.004
- Key Word:
- 铃蟾肽;P物质;迟慢兴奋性突触后电位;肠系膜下神经节;豚鼠
Abstract： 应用细胞内记录技术, 对铃蟾肽(bombesin, BOM)在豚鼠离体肠系膜下神经节(inferior mesenteric ganglion, IMG)非胆碱能兴奋性突触传递中的作用进行了研究.重复电刺激突触前结肠神经, 有74.3% (52/70) IMG细胞可诱发迟慢兴奋性突触后电位(ls-EPSP).在可引出ls-EPSP 的细胞中, 22% (4/18)细胞同时对BOM和SP敏感.用BOM持续灌流IMG, 可明显抑制对BOM敏感细胞的ls-EPSP, 对BOM不敏感细胞的ls-EPSP则无影响, 且BOM受体与SP受体间无交叉脱敏.BOM受体阻断剂tyr4[D-phe12]bombesin能明显可逆性地抑制BOM敏感细胞的ls-EPSP和去极化, 但对BOM不敏感细胞则无影响.研究结果提示, BOM可能是介导豚鼠IMG 细胞ls-EPSP的一种递质.
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