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Animal models of schizophrenia using different laboratory mouse strains
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.2003.04.003
- Key Word:
- 精神分裂症;动物模型;MK801;移动加快;刻板性动作;利培酮
Abstract： 基于精神分裂症的谷氨酸功能紊乱假说, 实验用N-甲基-D-天门冬氨酸(NMDA)非竞争性受体拮抗剂MK801 (5-甲基二氢二苯并环庚稀亚氨马来酸或地卓西平马来酸盐)作用于实验小鼠, 观察到类似精神分裂症的症状: 移动加快(hyperlocomotion)和刻板性动作(stereotypy), 建立了可用仪器测定的两项量化指标.根据作用于近交系BALB/c小鼠的MK801的剂量优化结果, 用0.6 mg/kg体重的MK801剂量初步建立了精神分裂症小鼠模型, 并用近交系C57BL/6小鼠成功重复了上述实验.进一步用系列剂量的MK801作用于远交群ICR小鼠, 同样也诱发了类似精神分裂症的症状.用目前临床上常用的抗精神分裂症药物利培酮作用于已建立的BALB/c小鼠和C57BL/6小鼠的精神分裂症模型, 结果表明利培酮能显著地抑制两品系模型小鼠的类似精神分裂症的症状.实验结果证明: 用MK801作用于实验小鼠建立精神分裂症动物模型是可行的.
- [1]A, Carlsson,L O, Hansson,N, Waters,etc.Neurotransmitter aberrations in schizophrenia: new perspectives and therapeutic implications.[J].1997,61(2).
- [2].Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia[J].1999,98(4).
- [3]J D, Griffith,J, Cavanaugh,J, Held,etc.Dextroamphetamine. Evaluation of psychomimetic properties in man.[J].1972,26.
- [4]T A, Ban,W, Guy,W H, Wilson.Description and distribution of the subtypes of chronic schizophrenia based on Leonhard's classification.[J].1984,2(3).
- [5]Nils-Erik Andén,Sherrel G. Butcher,Hans Corrodi,etc.Receptor activity and turnover of dopamine and noradrenaline after neuroleptics[J].1970,11(3).
- [6]Maria Carlsson,Arvid Carlsson.Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease[J].1990,13(7).
- [7]周怀梧主编.医药应用概率统计[M].1990.
- [8]D C, Javitt,S R, Zukin.Recent advances in the phencyclidine model of schizophrenia.[J].1991,148.
- [9]H J, Guan,J, Dai,X Z, Zhu.Atypical antipsychotic effects of quetiapine fumarate in animal models.[J].2000,21(3).