Aberrant neuronal expression of mitotic protein, tau and Bax in the rat brain after injection of Aβ 25-35 into the amygdala

( views:, downloads: )
Journal Title:
Volume 55, Issue 02, 2003
Key Word:


  • [1]Glenner GG, Wong CW. Alzheimer′s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120(3):885-890.
  • [2]Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wis-niewski HM. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 1986;261(13):6084-6089.
  • [3]Smith MZ, Nagy ZS, Esiri MM. Cell cycle-related protein expression in vascular dementia and Alzheimer′s disease. Neurosci Lett 1999;271(1):45-48.
  • [4]Vincent I, Jicha G, Rosado M, Dickson DW. Aberrant expression of mitotic Cdc2/Cyclin B kinase in degenerating neurons of Alzheimer′s disease brains. J Neurosci 1997;17(10):3588-3598.
  • [5]Husseman JW, Nochlin D, Vincent I. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol Aging 2000;21(6):815-828.
  • [6]Yankner BA. The pathogenesis of Alzheimer′s disease. Is amyloid beta-protein the beginning or the end? Ann NY Acad Sci 2000;924:26-28.
  • [7]Selkoe DJ.Toward a comprehensive theory for Alzheimer′s disease. Hypothesis: Alzheimer′s disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 2000; 924:17-25.
  • [8]Sambamurti K, Greig NH, Lahiri DK. Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer′s disease. Neuromolecular Med 2002;1(1):1-31.
  • [9]Sigurdsson EM, Lee JM, Dong XW, Hejna MJ, Lorens SA. Bilateral injections of amyloid-β 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects. Neurobiol Aging 1997;18(6):591-608.
  • [10]Sigurdsson EM, Lorens SA, Hejna MJ, Dong XW, Lee JM. Local and distant histopathological effects of unilateral amyloid-β 25-35 injections into the amygdala of young F344 rats. Neurobiol Aging 1996; 17(6):893-901.
  • [11]Wei JS (魏建设), Zhang LM, Huang YL, Zhu CQ, Sun FY. Okadaic acid induces the expression of glutamate transporter EAAT1 in the neurons of rat brain. Acta Physiol Sin (生理学报) 2002;54(4):287-293 (Chinese, English abstract).
  • [12]Simmons LK, May PC, Tomaselli KJ, Rydel RE, Fuson KS, Brigham EF, Wright S, Lieberburg I, Becker GW, Brems DN. Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro. Mol Pharmacol 1994;45(3):373-379.
  • [13]Mattson MP, Barger SW, Cheng B, Lieberburg I, Smith-Swintosky VL, Rydel RE, Davis D. Beta-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992;12(2):376-389.
  • [14]Kasa P, Papp H, Kovacs I, Forgon M, Penke B, Yamaguchi H. Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. Neurosci Lett 2000; 278(1):117-119.
  • [15]Hampel H, Teipel SJ, Bayer W, Alexander GE, Schwarz R, Schapiro MB, Rapoport SI, Moller HJ. Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer′s disease. J Neurol Sci 2002;194(1):15-19.
  • [16]Arriagada PV, Growdon JH. Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer′s disease. Neurology 1992;42(3):631-639.
  • [17]Jamada M, Mehraein P. Distribution of senile changes in the brain. The part of the limbic system in Alzheimer′s disease and senile dementia. Arch Psychiatr Nervenkr 1968;211:308-324.
  • [18]Grana X, Reddy EP. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases, growth suppressor genes and cyclin-dependent kinase inhibitors. Oncogene 1995;11(2):211-219.
  • [19]Nagy ZS, Esiri MM, Smith AD. The cell division cycle and the pathophysiology of Alzheimer′s disease. Neuroscience 1998;87(4):731-739.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn