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Interleukin-2 induced endothelium-dependent relaxation of rat thoracic aorta

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Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 1

DOI:: 10.3321/j.issn:0371-0874.2003.01.006

Key Word:: 白细胞介素-2;NO;胸主动脉环;内皮

Abstract：本文旨在研究白细胞介素-2 (interleukin-2, IL-2)对离体大鼠胸主动脉环收缩张力的作用及其可能机制.采用累积加药法, 检测IL-2对去氧肾上腺素(PE)和KCl预收缩的胸主动脉环收缩张力的影响.结果表明, IL-2 (1、10、100、1000 U/ml)对PE (10 μmol/L)预收缩的内皮完整血管环产生浓度依赖性的舒张作用, 而对KCl (120 mmol/L)预收缩的血管无作用.去除内皮后, IL-2的舒张作用被取消.用一氧化氮合酶抑制剂L-NAME (0.1 mmol/L)和鸟苷酸环化酶抑制剂亚甲蓝(10 μmol/L)预处理, 均可阻断IL-2的舒张血管作用.用环氧合酶抑制剂吲哚美辛(Indo, 10 μmol/L) 预处理可阻断IL-2的血管舒张作用.从上述观察结果推论, IL-2通过NO-鸟苷酸环化酶和环氧合酶途径产生内皮依赖的血管舒张作用.

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