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Prostaglandin inhibitor indomethacin inhibits afferent activities of Aδ and C units in the saphenous nerve of diabetic hyperalgesic rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2002.05.005
- Key Word:
- 痛过敏;消炎痛;单位放电;糖尿病;大鼠
Abstract： 实验观察了前列腺素(prostaglandins, PGs)合成限速酶非选择性环氧合酶(cyclo-oxygenase, COX)抑制剂消炎痛和外源性前列腺素E2 (prostaglandin E2, PGE2)对糖尿病痛过敏大鼠隐神经中Aδ单位和C单位传入活动的影响.结果发现, 糖尿病痛过敏大鼠Aδ单位和C单位的传导速度和它们的机械阈值显著降低, 少数Aδ单位(4/24)和C单位(2/18)具有自发活动.腹腔注射消炎痛后能明显缓解糖尿病痛过敏大鼠的机械性痛过敏, 并抑制自发放电.在消炎痛阻断内源性PGs合成后, 外源性PGE2能使糖尿病痛过敏组和对照组大鼠Aδ单位和C单位的机械阈值显著降低, 并诱发糖尿病痛过敏组大鼠3个Aδ单位(3/24)和1个C单位(1/18), 以及对照组大鼠2个Aδ单位(2/13)产生传入活动.结果提示, 在患糖尿病性神经病时, PG的合成和释放增多, 这些PGs敏化或和激活Aδ单位和C单位, 诱发糖尿病大鼠产生痛过敏和触诱发痛.
- [1]刘健,王克模,张巧俊,等.糖尿病痛过敏大鼠尾神经中传入单位对交感传出的反应[J].2001,(6).
- [2]刘健,王克模,曹东元,等.链脲佐菌素糖尿病大鼠尾神经中传入单位的反应特性[J].1996,(4).
- [3]Y O, Taiwo,J D, Levine.Effects of cyclooxygenase products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat.[J].1990,537(1-2).
- [4]A J, Boulton,J D, Ward.Diabetic neuropathies and pain.[J].1986,15(4).
- [5]R D, Treede,R A, Meyer,S N, Raja,etc.Peripheral and central mechanisms of cutaneous hyperalgesia.[J].1992,38(4).
- [6]胡三觉,陈敏,田巧莲,等.刺激交感神经对大鼠多觉型伤害性感受器诱发和自发放电的不同作用[J].1986,(3).
- [7]Y, Shir,Z, Seltzer.A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats.[J].1990,115(1).
- [8]Kingery WS.A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes.[J].1997,73(2).
- [9]刘健,王克模,曹东元,等.糖尿病性神经病患者桡神经浅支中传入单位的反应特性[J].1996,(4).
- [10]B, Lynn,S E, Carpenter.Primary afferent units from the hairy skin of the rat hind limb.[J].1982,238(1).
- [11]K, Mizumura,T, Kumazawa.Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their action--a study in canine testicular polymodal receptors.[J].1996,113.
- [12]Syriatowicz JP,Walker JS,Tracey DJ,etc.Hyperalgesia due to nerve injury: role of prostaglandins.[J].1999,94(2).
- [13]S T, Britland,R J, Young,A K, Sharma,etc.Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fibre pathology.[J].1992,48.
- [14]L. Wuarin-Bierman,G. R. Zahnd,F. Kaufmann,etc.Hyperalgesia in spontaneous and experimental animal models of diabetic neuropathy[J].1987,30(8).
- [15]J, Liu,K M, Wang,L Z, He,etc.[Effects of sympathetic efferent in diabetic hyperalgesia in rat].[J].1996,48(6).