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Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2002.05.003
- Key Word:
- 异质性;左室壁三层心肌细胞;动作电位;离子电流;兔
Abstract： 探讨兔左室壁三层心肌单个细胞的分离方法以及电生理特征.实验以胶原酶按二步消化法分离兔心肌细胞, 其中用剃须刀分离左室游离壁内、中、外三层心肌.采用全细胞膜片钳记录AP和离子电流.结果显示: (1) 中层细胞上的动作电位时程明显长于内膜下心肌和外膜下心肌, 且存在显著的1相切迹和2相驼峰; (2) 中层细胞的ICa, L和 Ito较内、外膜下的大, IK,s相反.可见三层心肌细胞上多种电流存在显著差异.
- [1]谢安,臧益民.细胞外Ba2+对内向整流钾通道的阻断作用[J].2000,(1).
- [2]T, Stankovicova,M, Szilard,I, De Scheerder,etc.M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart.[J].2000,45.
- [3]Hicks MN,Kane KA,Cobbe SM,etc.Functional, structural, and dynamic basis of electrical heterogeneity in healthy and diseased cardiac muscle: implications for arrhythmogenesis and anti-arrhythmic drug therapy.[J].1999,84(2).
- [4]Kozhevnikov DmitryO,Restivo Mark,Yamamoto Keiji,etc.Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns.[J].2002,105(9).
- [5]SERGE SICOURI,JEFFREY FISH,CHARLES ANTZELEVITCH.Distribution of M Cells in the Canine Ventricle[J].1994,5(10).
- [6]P, Taggart,P M, Sutton,T, Opthof,etc.Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia.[J].2001,50.
- [7]B, Huang,D, Qin,N, El-Sherif.Spatial alterations of Kv channels expression and K(+) currents in post-MI remodeled rat heart.[J].2001,52(2).