You Position: Home > Paper

Dysfunction of myocardial and vascular taurine transport in spontaneously hypertensive rats

( views:173, downloads:4 )
Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
5
DOI:
10.3321/j.issn:0371-0874.2002.05.001
Key Word:
牛磺酸;转运体;mRNA;自发性高血压大鼠;心肌;血管;taurine;transporter;mRNA;spontaneously hypertensive rat;myocardial;vessels

Abstract: The alterations of taurine transport and the expression of taurine transporter (TAUT) mRNA in myocardium and aortic wall were investigated in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. It was demonstrated that plasma taurine concentration and taurine release from myocardium and aortic wall in SHR were higher than those in WKY rats, whereas taurine content, taurine uptake and TAUT mRNA in myocardium and aortic wall of SHR were lower than those of WKY rats. In SHR, the maximal velocity (Vmax) of taurine transportration in myocardium and aortic wall was lower by 24% (P<0.05) and 35% (P<0.05) than that in WKY, their michaelis constants (Km) values were higher by 16% (P<0.05) and 39% (P<0.05), respectively. The results suggest that there is dysfunction of taurine transport in myocardium and aortic wall in SHR, which may be partly resulted from the decrease of TAUT activity and affinity, and down-regulation of TAUT gene expression.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn