You Position: Home > Paper
Effects of Bay K8644 and nifedipine on L-type Ca2+ channels in hypothalamic neurons of rats
( views:170, downloads:8 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSILOGOCA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2001.05.003
- Key Word:
- 下丘脑;L-型Ca2+通道;Bay K8644;nifedipine;膜片箝技术
Abstract： 采用神经元急性分离和膜片箝技术以及细胞贴附式方式记录通道活动, 探讨DHP类Ca2+通道激动剂Bay K8644及拮抗剂nifedipine对下丘脑神经元L-型Ca2+通道的影响. 结果显示, 在Bay K8644作用下, 通道开放形式发生变化, 明显可见多级开放; 通道平均开放时间、平均开放概率显著增加, 但单通道电导无明显变化.nifedipine的作用与Bay K8644相反. 结果提示, Bay K8644对下丘脑神经元L-型Ca2+通道有明显激动作用, nifedipine有显著抑制作用.
- [1]J.-F. Zhang,A.D. Randall,P.T. Ellinor,etc.Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons[J].1993,32(11).
- [2]M, Spedding,R, Paoletti.Classification of calcium channels and the sites of action of drugs modifying channel function.[J].1992,44(3).
- [3]Ezawa I,Kudo Y,Morita M,etc.Activation of dihydropyridine sensitive Ca2+ channels in rat hippocampal neurons in culture by parathyroid hormone.[J].1998,256(3).
- [4]Jensen MS,Lambert JD,Jensen K.Role of presynaptic L-type Ca2+ channels in GABAergic synaptic transmission in cultured hippocampal neurons.[J].1999,81(3).
- [5]W H, Griffith,L, Taylor,M J, Davis.Whole-cell and single-channel calcium currents in guinea pig basal forebrain neurons.[J].1994,71(6).
- [6]Chung MK,Kim HC.Voltage-dependent sodium and calcium currents in acutely isolated adult rat trigeminal root ganglion neurons.[J].1999,81(3).
- [7]T F, McDonald,S, Pelzer,W, Trautwein,etc.Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells.[J].1994,74(2).