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Relationship between dopamine and iron contents in the brain of Parkinsonian rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSILOGOCA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.2001.05.002
- Key Word:
- 帕金森病模型鼠;铁;甲磺酸去铁胺;黑质;纹状体;多巴胺
Abstract： 实验采用原子吸收分光光度法、快速周期伏安法、高效液相电化学检测等方法, 研究以6-羟基多巴(6-OHDA)制备的帕金森病(PD)模型大鼠黑质内铁含量的变化, 铁对多巴胺(DA)能神经元的直接毒性作用以及铁离子螯合剂甲磺酸去铁胺的神经保护作用.结果发现: (1) PD大鼠损毁侧黑质内铁含量为非标准PD大鼠的3倍左右; (2) PD大鼠损毁侧纹状体内铁含量无明显改变; (3)单纯注射6-OHDA的大鼠其损毁侧纹状体(CPu) DA的释放量和含量均明显降低; (4)侧脑室预先注射甲磺酸去铁胺, 再重复上述实验, 损毁侧CPu DA释放量和含量均无明显改变; (5)单侧黑质内注射40 μg FeCl3后, 大鼠损毁侧CPu内DA释放量和含量显著降低.上述结果提示, 6-OHDA可导致CPu DA释放量及含量减少, 此过程有铁的参与.由于铁可导致DA神经元死亡, 因此铁含量的增加可能是DA含量减少的原因之一, 甲磺酸去铁胺具有保护DA神经元的作用.
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