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Increase in amount and affinity of adenosine receptor in rat hippocampal cellular membranes induced by cerebral ischemic preconditioning and its protective effects on the neurons

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0371-0874.2001.04.006
Key Word:
缺血;预缺血处理;腺苷;腺苷受体;海马;脑

Abstract: 采用放射性配基结合法,测定大鼠全脑缺血后海马细胞膜腺苷(adenosine,ADO)受体数量及亲和力的变化,以探讨其与脑缺血耐受形成之间的关系。发现缺血6min即可导致海马组织明显的神经元延迟性死亡(delayedneuron death,DND),缺血3min不足以引起海马组织明显的DND;而经过3min预缺血处理,可明显减轻间隔1d后6min缺血引起的海马DND(P<0.01)。与此相对应,缺血3min再灌1和3d时,ADO受体数量及亲和力明显高于sham组(P<0.05),而缺血6min再灌1和3d时,ADO受体数量明显低于sham组(P<0.05),但亲和力高于sham组(P<0.05)。与单纯6min缺血再灌4h、1和3d时相比,3min预缺血+6min缺血(间隔1d)再灌后,ADO受体数量及亲和力均显著升高(P<0.05)。这些结果表明,脑预缺血处理可使大鼠海马细胞膜ADO受体数量增多,亲和力增强,并能对抗损伤性缺血引起的ADO受体数量减少,提示腺苷受体数量及亲和力的变化在脑缺血耐受形成过程中发挥了重要的作用。

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