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Suppression of glutamate neurotoxicity by 5-HT in hippocampal neurons

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0371-0874.2001.04.004
Key Word:
5-羟色胺 (5-HT);谷氨酸 (Glu);海马神经细胞;应激

Abstract: 为探讨5-羟色胺(5-HT)对过量谷氨酸(glutamate,Glu)神经毒性的影响,观察了5-HT存在时,过量Glu对海马细胞存活率、海马脑片CA1区群锋电位(populationspike,PS)及神经细胞膜Ca2+电流的影响。结果发现:5-HT可明显提高过量Glu作用下海马神经细胞的存活率,减缓Glu对海马脑片CA1区PS的降低作用;在细胞膜上,5-HT可明显减弱Glu诱导的Ca2+内向电流。推测,一定浓度的5-HT具有抑制过量Glu神经毒性的作用,其机制可能在于5-HT与细胞膜上特定的受体结合,抑制了Glu诱导的Ca2+内流。

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