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Role of calcium in the mechanism underlying the inhibitory effect of streptomycin on carotid sinus baroreflex in rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0371-0874.2000.06.005
- Key Word:
- 链霉素;颈动脉窦压力感受器反射;平均动脉压;窦内压;Ca2+ 激活性K+通道
Abstract： 在23只隔离灌流颈动脉窦区的麻醉大鼠上, 观察了链霉素(streptomycin, SM)对动脉压力感受器反射影响的离子机制.结果: (1) 用SM (200 μmol/L)隔离灌流大鼠颈动脉窦区时, 压力感受器机能曲线向右上方移位, 曲线最大斜率及反射性血压下降幅度均减小(P<0.01), 提示SM对压力感受器反射有抑制作用; (2)预先灌流高Ca2+溶液(4 mmol/L)后, 可部分消除SM (200 μmol/L)对压力感受器反射的抑制作用(P<0.01), 使其压力感受器机能曲线向左下方移位, 曲线的最大斜率由0.27±0.04增至0.37±0.02 (P<0.01), 反射性血压下降幅度由4.32±0.14 kPa增至6.18±0.17 kPa (P<0.01), 而阈压和饱和压则分别从10.29±0.29和27.26±0.42 kPa降至9.98±0.33 和25.22±0.38 kPa (P<0.05); (3) 用Ca2+通道激动剂Bay K 8644 (500 nmol/L)预处理, 可完全消除SM (200 μmol/L)对压力感受器反射的抑制效应; (4)预先给予Ca2+激活性K+通道阻断剂(charybdotoxin, ChTX, 100 nmol/L), 对压力感受器反射无明显影响, 加入SM后仍呈现抑制作用.以上结果表明, SM可能是通过抑制颈动脉窦压力感受器中机械敏感性通道的Ca2+内流而发挥作用.
- [1]尹彤,陈爽,何瑞荣.链霉素对颈动脉窦压力感受器反射的抑制作用[J].2000,(3).
- [2]武宇明,何瑞荣.缓激肽抑制麻醉大鼠颈动脉窦压力感受器反射[J].1999,(3).
- [3]P, Grigg.Biophysical studies of mechanoreceptors.[J].1986,60.
- [4]W R, Saum,S, Ayachi,A M, Brown.Actions of sodium and potassium ions on baroreceptors of normotensive and spontaneously hypertensive rats.[J].1977,41.
- [5]H, Ohmori.Mechano-electrical transduction currents in isolated vestibular hair cells of the chick.[J].1985,359.
- [6]易小林.微型计算机控制的颈动脉窦区自动灌流系统[J].1993,(2).
- [7]Francois Gannier,Edward White,Alain Lacampagne,etc.Streptomycin reverses a large stretch induced increase in [Ca2+]i in isolated guinea pig ventricular myocytes[J].1994,28(8).
- [8]Hay, M.,Kunze, D. L..An intermediate conductance calcium-activated potassium channel in rat visceral sensory afferent neurons[J].1994,167(1).
- [9]Hajduczok G,Chapleau M W,Ferlic R J,etc.Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-activated channels.[J].1994.
- [10]M C, Andresen,S, Kuraoka,A M, Brown.Individual and combined actions of calcium, sodium, and potassium ions on baroreceptors in the rat.[J].1979,45(6).
- [11]T D, Parsons,A L, Obaid,B M, Salzberg.Aminoglycoside antibiotics block voltage-dependent calcium channels in intact vertebrate nerve terminals.[J].1992,99.
- [12]M, Hay,D L, Kunze.Calcium-activated potassium channels in rat visceral sensory afferents.[J].1994,639(2).
- [13]A H, Salmon,J L, Mays,G R, Dalton,etc.Effect of streptomycin on wall-stress-induced arrhythmias in the working rat heart.[J].1997,34.
- [14]Bhalla RC,Abboud FM,Chapleau MW,etc.Mechanical stimulation increases intracellular calcium concentration in nodose sensory neurons.[J].1995,66(2).
- [15]Sullivan M. J.,Sharma R. V.,Wachtel R. E.,etc.Non\u00a0Voltage-Gated Ca2+ Influx Through Mechanosensitive Ion Channels in Aortic Baroreceptor Neurons[J].1997.
- [16]B K, Slinker,A H, Tobias.Previous-beat contraction history is not influenced by mechanosensitive ion channel blockade.[J].1996,32.