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17β-estradiol inhibits carotid sinus baroreflex in male rats
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0371-0874.2000.06.001
- Key Word:
- 雌激素;17β-雌二醇;它莫西芬;压力感受器反射;平均动脉压;非基因组效应
Abstract： 采用隔离灌流麻醉雄性大鼠颈动脉窦技术, 观察了17β-雌二醇(E2)对颈动脉窦压力感受器反射的影响.结果如下: (1)以E2 (10 μmol/L)隔离灌流颈动脉窦区时, 压力感受器机能曲线向右上方移位, 曲线最大斜率(peak slope, PS)由0.49±0.03降至0.25±0.01 (P<0.01), 反射性血压下降幅度(reflex decrease, RD)由7.37±0.42 kPa 降至3.49±0.20 kPa (P<0.001), 阈压(threshold pressure, TP)和饱和压(saturation pressure, SP)分别由9.52±0.68 kPa和24.53±0.48 kPa增至13.3±0.11 kPa (P<0.001)和27.52±0.20 kPa (P<0.01), 其中PS、 RD、 TP和SP呈明显的剂量依赖性; (2)用雌激素受体阻断剂tamoxifen (1、 5、 10、 30 μmol/L)预处理后, 不能阻断E2对压力感受器反射的抑制作用; (3)预先灌流NO合酶阻断剂(L-NAME, 100 μmol/L), 可完全消除E2 (10 μmol/L) 对压力感受器反射的抑制效应.以上结果表明, 17β-雌二醇可通过非基因组机制抑制大鼠颈动脉窦压力感受器反射, 其效应系E2引起血管内皮细胞释放NO所致.
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