MKP-1 regulates the cardiomyocyte hypertrophic responses induced by angiotensin Ⅱ

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LIU Pei-Qing()
LU Wei()
WANG Ting-Huai()
PAN Jing-Yun()
Journal Title:
Volume 52, Issue 05, 2000
Key Word:


  • [1]Watson PA. Mechanical activation of signaling pathways in the cardiovascular system. Trends Cardiovasc Med, 1996, 6: 73~79.
  • [2]Menard J, Campbell DJ, Azizi M et al. Synergistic effects of ACE inhibition and AngⅡantagonism on blood pressure,cardiac weight, and renin in spontaneously hypertensive rats. Circulation, 1997, 96: 3072~3078.
  • [3]Post RP,Goldstein D, Thuerauf DJ et al. Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocyte. J Biol Chem, 1996, 271 (14): 8452~8458.
  • [4]Anita MP, Rim CS, Yao H et al. A novel mitogen-activated protein kinase phosphatase. J Biol Chem, 1996, 270 (24): 8452~8458.
  • [5]Fuller SJ, Davies EL, Gillespie BJ et al. Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes. Biochem J, 1997, 323 (Pt 2): 313~319.
  • [6]Gotoh Y, Nishida E, Yamashita et al. Microtubule associated protein kinase activated by nerve growth factor and epidermal growth factor in PC12 cells: identity with the mitogen-activated protein kinase of fibroblastic cells. Eur J Biochem, 1990, 349: 661~669.
  • [7]Cook SJ, Beltman J, Cadwallader KA et al. Regulation of mitogen-activated protein kinase phosphatase 1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells. J Biol Chem, 1997, 272 (20): 13309~13319.
  • [8]Kusari AB, Byon J, Bandyopadhyay D et al. Insulin-induced mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) attenuates insulin-stimulated MAP kinase activity: a mechanism for the feedback inhibition of insulin signaling. Mol Endocrinol, 1997, 11 (10): 1532~1543.
  • [9]Duff JL, Monia BP, Berk BC et al. Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase-1 (MKP-1) in vascular smooth muscle cells. Effect of actinomycin D and antisense oligonucleotides. J Biol Chem, 1995, 270: 7161~7166.
  • [10]Kojima M, Shiojima I, Yamazaki T et al. Angiotensin Ⅱ receptor antagonist TCV-116 induces regression of hypertensive left ventricular hyper~trophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro. Circulation, 1994, 89: 2204~2211.
  • [11]Martin A. Signaling pathways in cardiac myocyte hypertrophy. J Mol Cell Cardiol, 1997, 29: 2873~2892.
  • [12]Anita MP, Rim CS, Yao H et al. A novel mitogen-activated protein kinase phosphatase. J Biol Chem, 1996, 270 (24): 8452~8458.
  • [13]Darbre A. Analytic methods. In: Darbre A eds. Practical Protein Chemistry: A Handbook. New York: Wiley, 1986, 227~335.
  • [14]Ueki K, Matsuda S, Tobe K et al. Feedback regulation of mitogen-activated protein kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. J Bio Chem, 1994, 269 (22): 15756~15761.
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