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Signal transduction pathway for antral smooth muscle cell contraction induced by motilin and gastrin in rats

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Author:
No author available
Journal Title:
ACTA PHYSIOLOGICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0371-0874.2000.04.002
Key Word:
胃动素;胃泌素;收缩;G蛋白;磷脂酶C

Abstract: 应用大鼠游离胃窦平滑肌细胞, 观察胃动素和胃泌素对胃窦平滑肌细胞收缩作用的胞内信号转导通路.结果显示: (1)胃动素和胃泌素对胃窦平滑肌细胞均有收缩作用; (2) Gαi-3抗体可抑制胃动素和胃泌素加强胃窦平滑肌细胞的收缩, 胃动素、胃泌素明显增加Gαi-3抗体与[35S]GTPγS的结合; (3)磷脂酶C抑制剂U-73122、三磷酸肌醇受体拮抗剂肝素可抑制胃动素和胃泌素引起的胃窦平滑肌细胞的收缩.结果表明: 胃动素和胃泌素通过兴奋与磷脂酶C耦联的Gi蛋白, 产生三磷酸肌醇, 激发胃窦平滑肌细胞的收缩反应.

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