Paper - WANFANG MED ONLINE

You Position: Home > Paper

Regulation of inflammatory responses by MAPK signal transduction pathways

( views:985, downloads:807 )

Author:: No author available

Journal Title:: ACTA PHYSIOLOGICA SINICA

Issue:: 4

DOI:: 10.3321/j.issn:0371-0874.2000.04.001

Key Word:: 丝裂原活化蛋白激酶;信号转导;炎症反应

Abstract：丝裂原活化蛋白激酶(mitogen-activated protein kinase, MAPK)是生物体内重要的信号转导系统之一, 参与介导生长、发育、分裂、分化、死亡以及细胞间的功能同步等多种细胞过程.在哺乳动物细胞中已发现和克隆了ERK、JNK/SAPK、p38/RK、ERK5/BMK1 四个MAPK亚族.这些MAPK能被多种炎性刺激所激活, 并对炎症的发生、发展起重要调控作用.研究感染和炎症反应过程中这些MAPK被激活的机制及其生物学效应, 探讨MAPK特异性抑制剂的药理学作用及分子基础, 对于感染的防治及炎症反应的控制有着广泛的应用前景.

Reference

[1]J M, Kyriakis,J, Avruch.Sounding the alarm: protein kinase cascades activated by stress and inflammation.[J].1996,271(40).
[2]Miller BW,Guan Z,Buckman SY,etc.Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells.[J].1998,273(44).
[3]DaSilva C,Dumont FJ,Staruch MJ,etc.Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production.[J].1998,160(6).
[4]Li, Z.,Jiang, Y.,Ulevitch, R.J.,etc.The Primary Structure of p38: A New Member of p38 Group of MAP Kinases[J].1996,228(2).
[5]姜勇.LPS介导细胞激活的信号转导：从CD14到P38MAPK通路的研究[J].1999,(1).
[6]Zhu W,Han J,New L,etc.PRAK, a novel protein kinase regulated by the p38 MAP kinase.[J].1998,17(12).
[7]姜勇,刘爱华,黄巧冰,等.p38 MAPK参与LPS诱导RAW细胞TNF-α基因表达的调控[J].1999,(1).
[8]English JM,Cobb MH,Baer R,etc.Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.[J].1998,273(7).
[9]Lee, John C.,Laydon, Jeffrey T..A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.[J].1994,372(6508).
[10]Lin S,Jiang Y,Guo W,etc.Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).[J].1996,271(30).
[11]Kumar S,Kassis S,Lee JC,etc.P38 Mitogen-Activated Protein Kinase Inhibitors--Mechanisms and Therapeutic Potentials.[J].1999,82(2).
[12]姜勇,韩家淮.P38MAPK信号传导通路[J].1999,(3).
[13]Hacker C.,Tebben A.,Liverton N.,etc.Molecular basis for p38 protein kinase inhibitor specificity[J].1998,37(47).
[14]J, Han,J D, Lee,L, Bibbs,etc.A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.[J].1994,265(5173).
[15]Guan ZH.,Baier LD.,Morrison AR..P38 Mitogen-Activated Protein Kinase Down-Regulates Nitric Oxide and up-Regulates Prostaglandin E(2) Biosynthesis Stimulated by Interleukin-1-Beta[J].1997,272(12).
[16]J, Han,Y, Jiang,Z, Li,etc.Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.[J].1997,386(6622).
[17]Han JH.,Guan KL.,Li ZJ.,etc.Structure-Function Studies of P38 Mitogen-Activated Protein Kinase - Loop 12 Influences Substrate Specificity and Autophosphorylation, but Not Upstream Kinase Selection[J].1997,272(17).
[18]Kovesdi I,Bruder JT.Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression[J].1997,71(1).
[19]Read MA,Pierce JW,Whitley MZ,etc.Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways.[J].1997,272(5).
[20]Feng LL.,New LG.,Dipadova F. Ulevitch RJ.,etc.Characterization of the Structure and Function of the Fourth Member of P38 Group Mitogen-Activated Protein Kinases, P38-Delta[J].1997,272(48).
[21]Adderley SR,Fitzgerald DJ.Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2.[J].1999,274(8).