Interleukin-2 stimulates the proliferation of cultured RC-4B/C pituitary adenoma cell line

( views:, downloads: )
WANG Gao-Feng()
ZHU Yun-Long()
CHEN Jian-Kang()
ZHANG Wan-Hui()
ZHONG Yan-Qing()
HU Yu-Zhen()
WANG Fu-Zhou()
Journal Title:
Volume 52, Issue 03, 2000
Key Word:


  • [1]Robb RJ. Interleukin-2: the molecule and its function. Immunol Today, 1984, 5: 203~209.
  • [2]Arzt E, Stelzer G, Renner U et al. Interleukin-2 and inter~leukin-2 receptor expression in human corticotropic adenoma and murine pituitary cell cultures. J Clin Invest, 1992, 90: 1944~1951.
  • [3]Arzt E, Buric R, Stelzer G et al. Interleukin involvement in anterior pituitary cell growth regulation: effect of IL-2 and IL-6. Endocrinology, 1993, 132: 459~467.
  • [4]Petitto JM, Huang Z, Rinker CM et al. Isolation of IL-2 re~cep~tor-beta cDNA clones from AtT-20 pituitary cells: constitutive expression and role in signal transduction. Neuropsychopharmacology, 1997, 17: 57~66.
  • [5]Wang GF, Zhu YL, Hu YZ et al. Effect of interleukin-2 on proliferation of cultured rat anterior pituitary cells. Chin J Physiol Sci, 1997, 13: 129~136.
  • [6]吕宝璋, 田英主编. 受体学概论. 北京: 科学出版社. 1991年, 213~223.
  • [7]Haugen PK, Letourneau PC. Interleukin-2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth. J Neurosci Res, 1990, 25: 443~452.
  • [8]Hurbain KI, Berault A, Noel N et al. Gonadotropes in a novel rat pituitary tumor cell line, RC-4B/C. Establishment and partial characterization of the cell line. In Vitro Cell Dev Biol, 1990, 26: 431~440.
  • [9]Taniguchi T, Minami Y. The IL-2/IL-2 receptor system: a current overview. Cell, 1993, 73: 5~8.
  • [10]Taniguchi T, Miyazaki T, Minami Y et al. IL-2 signaling involves recruitment and activation of multiple protein tyrosine kinases by the IL-2 receptor. Ann NY Acad Sci, 1995, 766: 235~244.
  • [11]Howard OM, Kirken RA, Garcia GG et al. Structural do~mains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex formation. Biochem J, 1995, 306: 217~224.
  • [12]Chen TC, Hinton DR, Zidovetzki R et al. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab-Invest, 1998, 78: 165~174.
  • [13]Neumann M, Grieshammer T, Chuvpilo S et al. RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J, 1995, 14: 1991~2004.
  • [14]Newton CJ, Arzt E, Stalla GK. Involvement of the estrogen receptor in the growth response of pituitary tumor cells to interleukin-2. Biochem Biophy Res Commun, 1994, 205: 1930~1937.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615