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Antiarrhythmic and antioxidative effects of intermittent hypoxia exposure on rat myocardium
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.2000.02.001
- Key Word:
- 间歇性低氧;心律失常;超氧化物歧化酶、丙二醛;适应;心脏
Abstract： 利用结扎在体大鼠冠脉方法研究不同时间间歇性低氧处理对缺血、再灌注心律失常以及心肌超氧化物歧化酶(SOD)、丙二醛(MDA)的影响, 并与连续性低氧相比较.实验结果如下: (1) 间歇性低氧(intermittent hypoxia exposure)28 d (IH28)、42 d (IH42)、间歇性低氧28 d后1周 (PIH28-1W)、2周 (PIH28-2W)和连续性低氧 (continued hypoxia exposure) 28 d (CH28)、42 d (CH42)大鼠, 缺血和再灌注心律失常评分明显低于对照组;(2)IH28、IH42、CH28、CH42、PIH28-1W、PIH28-2W及间歇性低氧28 d后3周 (PIH28-3W)大鼠心肌的SOD明显高于对照组;而间歇性低氧14 d (IH14)、IH28、IH42、CH28、CH42、PIH28-1W及PIH28-2W大鼠心肌的MDA明显低于对照组.实验结果表明: 间歇性低氧处理28 d和42 d具有明确的抗缺血和再灌注心律失常作用, 此作用与心肌抗氧化能力增强有关.抗心律失常作用于间歇性低氧处理14 d后逐渐发生, 脱离低氧处理后可有效维持2周左右.
- [1]Hiroshi Ohkawa,Nobuko Ohishi,Kunio Yagi.Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction[J].1979,95(2).
- [2]Stefan MARKLUND,Gudrun MARKLUND.Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase[J].1974,47(3).
- [3]Johnston K. M.,MacLeod B. A.,Walker M. J. A..Responses to ligation of a coronary artery in conscious rats and the actions of antiarrhythmics[J].1983.
- [4]S. X.PEI,X. J.CHEN,B. Z.SI REN,etc.Chronic Mountain Sickness in Tibet[J].1989,71(3).
- [5]Zhuang J.-G.,Zhou Z..Protective Effects of Intermittent Hypoxic Adaptation on Myocardium and Its Mechanisms[J].1999,8(4-5).
- [6]D X, Tan,L C, Manchester,R J, Reiter,etc.Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin.[J].1998,25(3).