Neural control of the compensatory increase of testosterone in hemicastrated adult male rats
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.2000.01.004
- Key Word:
- 成年大鼠;睾丸去神经支配;半去势;睾酮分泌;促性腺激素;adult rat;testicular denervations;unilateral castrations;testosterone;gonadotropin
Abstract： It is unclear why the concentration of testosterone increases in the testicular vein after hemicastration without corresponding alteration in gonadotropins. The present work was undertaken to examine whether the testosterone levels could be modified by denervation of the testis in adult rats. Both systemic and testicular blood samples were collected either immediately before or 6 and 24 hours after hemicastration from the rats two weeks after denervation of either inferior spermatic nerves (ISN) or ISN plus superior spermatic nerves (ISN-SSN). Increase of testicular testosterone induced by hemicastration was significantly (P<0.05) inhibited in these rats, as compared with the sham animals (at 6 and 24 hours, ISN vs sham: 16.00±3.35 vs 42.72±13.85 and 26.93±8.68 vs 71.16±13.30 whilst ISN-SSN vs sham: 31.63±7.92 vs 60.61±18.11 and 27.70±8.93 vs 93.92±19.73 ng/ml, respectively), whereas no significant change in LH was observed in all the experimental groups. FSH underwent no alteration in all the ISN denervation groups, but a significant elevation was observed in the ISN-SSN denervation groups (P<0.05) before hemicastration. Therefore, it appears that the change in FSH is not the cause of the inhibition of testosterone increase in the hemicastrated rats after testicular denervation and that ISN plays an active role in regulation of testosterone increase induced by hemicastration.
- [1]BAO CHANG ZHU,SARA R. CHIOCCHIO,ANGELA M. SUBURO,etc.Monoaminergic and Peptidergic Contributions of the Superior and the Inferior Spermatic Nerves to the Innervation of the Testis in the Rat[J].1995,16(3).
- [2]Farnworth PG.Gonadotrophin secretion revisited. How many ways can FSH leave a gonadotroph?[J].1995,145(3).
- [3]O O, Anakwe,P R, Murphy,W H, Moger.Characterization of beta-adrenergic binding sites on rodent Leydig cells.[J].1985,33.
- [4]L A, Baker,T T, Turner.Leydig cell function after experimental testicular torsion despite loss of spermatogenesis.[J].1900,16.
- [5]P A, Halban,J C, Irminger.Sorting and processing of secretory proteins.[J].1994,299 ( Pt 1).
- [6]A I, Frankel,E J, Mock,J C, Chapman.Hypophysectomy and hemivasectomy can inhibit the testicular hemicastration response of the mature rat.[J].1984,30.
- [7]Dr. JANINE L. BROWN,PRABIR K. CHAKRABORTY.Comparison of Compensatory Pituitary and Testicular Responses to Hemicastration Between Prepubertal and Mature Rats[J].1991,12(2).
- [8]FRANKEL A. I.,WRIGHT W. W..The Hemicastrated Rat: Definition of a Model for the Study of the Regulation of Testicular Steroidogenesis[J].1982.
- [9]A I, Frankel,J C, Chapman,B, Cook.The testicular response to hemicastration in the male rat cannot be maintained in vitro.[J].1989,121(1).
- [10]A L, Favaretto,T L, Lamano-Carvalho,A L, Ferreira,etc.Effect of spermatic cord phenolization on the spermatogenetic and secretory activities of adult rat testes.[J].1986,19.
- [11]T, Furuya.Onset of compensatory hypertrophy of interstitial tissue and Leydig cells in rats hemicastrated around the time of puberty.[J].1990,42.
- [12]M L, Vitale,M J, Villar,S R, Chiocchio,etc.Dorsal raphe lesion alters the estrous cycle and the preovulatory gonadotropin release.[J].1987,46.
- [13]Frankel A. I.,Chapman J. C.,Cook B..Testes are asymmetric in the testicular hemicastration response of the male rat[J].1989.
- [14]M, Rauchenwald,W D, Steers,C, Desjardins.Efferent innervation of the rat testis.[J].1995,52.
- [15]M. B. Campos,M. L. Vitale,M. N. Ritta,etc.Catecholamine distribution in adult rat testis[J].1990,22(3).
- [16]JANINE L. BROWN PhD,KRISTINE D. DAHL,PRABIR K. CHAKRABORTY.Effects of Follicular Fluid Administration on Serum Bioactive and Immunoreactive FSH Concentrations and Compensatory Testosterone Secretion in Hemicastrated Adult Rats[J].1991,12(4).
- [17]J P, Preslock,S M, McCann.Short-term effects of vasoligation upon plasma follicle-stimulating hormone, luteinizing hormone, and prolactin in the adult rat: further evidence for a direct neural connection between the testes and the central nervous system.[J].1985,33.
- [18]I. GERENDAI,A. NEMESKERI,V. CSERNUS.The Effect of Neonatal Vasectomy on Testicular Function[J].1986,18(4).
- [19]Csernus V,Gerendai I,Voko Z,etc.Involvement of a direct neural mechanism in the control of gonadal functions.[J].1995,53(1).
- [20]W J, Debertin,D K, Pomerantz.An investigation of the requirement for increased LH secretion during the compensatory response in androgen secretion after unilateral castration of the adult rat.[J].1900,13(3).
- [21]W H, Moger,O O, Anakwe.Propranolol inhibits the compensatory increase in androgen secretion after unilateral orchidectomy in rats.[J].1986,76.
- [22]MOCK E. J.,FRANKEL A. I..Response of Testosterone to Hemicastration in the Testicular Vein of the Mature Rat[J].1982.
- [23]T. L. Lamano Carvalho,M. A. Guimaräes,W. G. Kempinas,etc.Effects of guanethidine-induced sympathectomy on the spermatogenic and steroidogenic testicular functions of prepubertal to mature rats[J].1996,28(2).
- [24]DAVID K. POMERANTZ,WERNER J. DEBERTIN,BERNARD ROBAIRE.The Patterns of LH Secretion in Adult Male Rats Associated with Compensatory Androgen Secretion by the Testis Remaining after Unilateral Orchidectomy[J].1991,637(1).
- [25]Chiocchio S. R.,Suburo A. M.,Vladucic E.,etc.Differential Effects of Superior and Inferior Spermatic Nerves on Testosterone Secretion and Spermatic Blood Flow in Cats 1[J].1999.
- [26]M B, Campos,M L, Vitale,R S, Calandra,etc.Serotonergic innervation of the rat testis.[J].1990,88.