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ROLE OF RED NUCLEUS IN INHIBITING NOCICEPTIVE RESPONSES OF RAT SPINDLE AFFERENT
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.1999.04.004
- Key Word:
- 红核;肌梭;WDR神经元;镇痛
Abstract： 本实验用玻璃微电极细胞外记录方法, 观察了刺激红核对皮肤强电刺激诱发的大鼠脊髓背角广动力范围(wide dynamic range, WDR)神经元长潜伏期反应(C-反应)的作用, 及红核对琥珀胆碱(succinylcholine, SCH)诱发的肌梭传入抑制WDR神经元C-反应效应的影响. 结果表明: 电刺激红核对WDR神经元C-反应具有抑制作用, 此作用可被静注噻庚啶明显减弱. 静脉注射SCH对WDR神经元C-反应有明显抑制作用, 损毁单侧红核后, SCH对WDR神经元C-反应的抑制效应明显减弱. 结果提示, 5-HT参与红核的痛下行抑制作用, 在肌梭传入镇痛中红核起着一定的作用.
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