You Position: Home > Paper
EFFECT OF β-ENDORPHIN ON PLASMA SIALIC ACID LEVEL IN RATS AND THE RELATIONSHIP WITH THE IMMUNE FUNCTION
( views:126, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1999.03.003
- Key Word:
- 血浆;唾液酸;β-内啡肽;侧脑室;弓状核区;淋巴细胞;大鼠
Abstract： 实验选择体重200～250g健康Wistar大鼠64只,采用麻醉大鼠中枢微量注射、分光光度测定法及免疫组织化学法,研究侧脑室、弓状核(ARC)区注射β-内啡肽(β-EP)对大鼠血浆唾液酸(SA)水平的影响及与免疫功能的关系.结果表明:(1)侧脑室注射β-EP可明显降低血浆SA水平; (2)血浆SA水平在ARC区注射β-EP后明显降低,此效应可被M胆碱受体阻断剂阿托品或切断双侧颈迷走神经所阻断; (3)ARC区注射β-EP后,外周血CD3,CD4明显升高,CD8明显降低,CD4/CD8比值升高.以上结果提示,中枢应用β-EP可降低血浆SA水平,ARC可能是主要的中枢作用部位,其机制与M胆碱能受体密切相关,可能是通过副交感神经实现此效应,且机体的细胞免疫功能是增强的.
- [1]陈文芳,陈家津,陈蕾.兴奋下丘脑弓状核神经元降低大鼠血浆唾液酸水平的作用[J].1995,(6).
- [2]P, Limonta,D, Dondi,R, Maggi,etc.Neonatal organization of the brain opioid systems controlling prolactin and luteinizing hormone secretion.[J].1989,124(2).
- [3]S R, Hull,R A, Laine,T, Kaizu,etc.Structures of the O-linked oligosaccharides of the major cell surface sialoglycoprotein of MAT-B1 and MAT-C1 ascites sublines of the 13762 rat mammary adenocarcinoma.[J].1984,259.
- [4]Domański E.,Romanowicz K.,Kerdelhué B..Enhancing Effect of Intracerebrally Infused β-Endorphin Antiserum on the Secretion of Cortisol in Foot-Shocked Sheep[J].1993,57(1).
- [5]P, Emmelot.Biochemical properties of normal and neoplastic cell surfaces; a review.[J].1973,9(5).
- [6]C D, Conover,R O, Kuljis,J, Rabii,etc.Beta-endorphin regulation of luteinizing hormone-releasing hormone release at the median eminence in ewes: immunocytochemical and physiological evidence.[J].1993,57.
- [7]M T, Debanne,E, Regoeczi.Subcellular distribution of human asialotransferrin type 3 in the rat liver.[J].1981,256(21).