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RAPID EFFECTS OF HYDROCORTISONE ON THE CHOLINERGIC SYNAPTIC TRANSMISSION OF B NEURONS IN BULLFROG SYMPATHETIC GANGLIA
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- Author:
- No author available
- Journal Title:
- ACTA PHTYSIOLOGOCA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0371-0874.1999.02.005
- Key Word:
- 皮质醇;牛蛙交感神经节;快速作用;突触传递
Abstract： 在离体灌流的牛蛙交感神经节标本上, 电刺激节前纤维, 细胞内记录B细胞的电活动, 观察给予皮质醇对B细胞突触传递的快速作用.主要结果有: (1)电刺激节前纤维, 细胞内记录170个B细胞的动作电位, 给予皮质醇后0.5～3 min内, 52个B细胞的突触传递发生脱漏甚至完全阻断, 有明显的量效关系.甾体激素胞内受体阻断剂RU38486可部分阻断这种作用.(2)蛋白合成抑制剂放线菌酮不能阻断皮质醇的快速阻断作用.(3)阿托品阻断M受体后, 皮质醇对B细胞突触传递的快速阻断作用增强.上述结果提示, 皮质醇通过非基因组机制对牛蛙交感神经节B细胞的突触传递产生快速阻断作用.
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