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STRESS AND DIETARY SALT INTAKE IN THE PATHOGENESIS OF HYPERTENSION: ROLE OF THE RENAL AND SYMPATHETIC NERVOUS SYSTEM
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0371-0874.1999.01.002
- Key Word:
- 应激;高盐饮食;高血压;肾脏机制;交感神经系统
Abstract： 本工作采用电生理、生化、放免、电镜等方法,探讨了慢性应激和盐致高血压大鼠交感神经系统和肾脏功能的改变.实验在雄性SD大鼠上进行.结果表明: (1)高盐大鼠肾血浆流量(RPF)和尿钠排泄明显增加,而应激大鼠RPF显著下降.(2)电镜显示高盐大鼠近曲和远曲小管上皮细胞及线粒体变大,应激则使细胞萎缩、线粒体变小.(3)高盐大鼠肾皮质Na-K-ATP酶活性下降,应激可使其恢复.(4)频谱分析显示应激大鼠低频波动(0.2～0.9 Hz)明显增加.(5)应激导致大鼠肾素活性(PRA)及血管紧张素Ⅱ(ANGⅡ)水平升高,并能使高盐大鼠低PRA和ANGⅡ水平升高.(6)大鼠去除双侧肾神经后,应激无法造成血压升高、RPF下降和PRA、ANGⅡ上升.上述结果提示: 肾交感神经系统兴奋性增加介导的肾脏机制,可能在应激和/或盐致高血压发病过程中具有重要作用.
- [1]Anderson D E.Interactions of Stress, Salt, and Blood Pressure[J].1984.
- [2]W H, Waugh.Photometry of inulin and polyfructosan by use of a cysteine/tryptophan reaction.[J].1977,23.
- [3]HOLGER NILSSON,DANIEL ELY,PETER FRIBERG,etc.Effects of high and low sodium diets on the resistance vessels and their adrenergic vasoconstrictor fibre control in normotensive (WKY) and hypertensive (SHR) rats[J].1985,125(2).
- [4]A.Steptoe.Stress mechanisms in hypertension.[J].1986,62(729).
- [5]D L, Clough.Inhibition of rat cardiac and renal Na+,K+-ATPase by high sodium concentrations and vanadate.[J].1985,37(9).
- [6]Abboud F. M..The sympathetic system in hypertension. State-of-the-art review[J].1982.
- [7]J P, Koepke,G F, DiBona.Central adrenergic receptor control of renal function in conscious hypertensive rats.[J].1986,8(2).