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THE MECHANISM ON HYPERPOLARIZATION OF MEMBRANE POTENTIAL INDUCED BY ADENOSINE IN FROG MELANOTROPHS
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0371-0874.1998.05.004
- Key Word:
- 促黑素细胞;膜片箝技术;K+电流;Ih
Abstract： 通过对青蛙垂体中叶促黑素细胞的实验已发现,腺苷激活A1型腺苷受体后可引起细胞膜的超极化同时停止自发性动作电位的发放,但此现象所涉及的离子机制尚不清楚.本实验采用膜片箝技术的全细胞电流、电压记录和细胞吸附单通道电流记录方法,对此电流进行了探讨.实验结果表明:腺苷所致的细胞膜超极化是由于增加了非电压激活的钾离子通道的开放,而对超极化电压激活的内向阳离子电流(Ih)没有影响.
- [1]J.A. Valentijn,E. Louiset,H. Vaudry,etc.Dopamine-induced inhibition of action potentials in cultured frog pituitary melanotrophs is mediated through activation of potassium channels and inhibition of calcium and sodium channels[J].1991,42(1).
- [2]Bauer C K,Meyerhof W,Schwarz J R.An inward-rectifying K+ current in clonal rat pituitary cells and its modulation by thyrotrophin-releasing hormone.[J].1990,429(1).
- [3]E, Louiset,L, Cazin,M, Lamacz,etc.Patch-clamp study of the ionic currents underlying action potentials in cultured frog pituitary melanotrophs.[J].1988,48.
- [4]Jack A. Valentijn,Estelle Louiset,Hubert Vaudry,etc.Involvement of non-selective cationic channels in the generation of pacemaker depolarizations and firing behaviour in cultured frog melanotrophs[J].1991,560(1-2).
- [5]P J, Williams,B A, MacVicar,Q J, Pittman.A dopaminergic inhibitory postsynaptic potential mediated by an increased potassium conductance.[J].1989,31(3).
- [6]R A, Olsson,J D, Pearson.Cardiovascular purinoceptors.[J].1990,70.
- [7]M. C. TONON,L. DESRUES,M. LAMACZ,etc.Multihormonal Regulation of Pituitary Melanotrophs[J].1993,680(1).
- [8]L O, Trussell,M B, Jackson.Adenosine-activated potassium conductance in cultured striatal neurons.[J].1985,82.
- [9]H C, Pape,D A, McCormick.Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current.[J].1989,340(6236).
- [10]W S, Spielman,L J, Arend.Adenosine receptors and signaling in the kidney.[J].1991,17.
- [11]C.Alzheimer,G.tenBruggencate.Postsynaptic inhibition by adenosine in hippocampal CA3 neurons: Co2+-sensitive activation of an inwardly rectifying K+conductance[J].1991,419(3).
- [12]L O, Trussell,M B, Jackson.Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons.[J].1987,7(10).
- [13]L J, Dorflinger,A, Schonbrunn.Adenosine inhibits prolactin and growth hormone secretion in a clonal pituitary cell line.[J].1985,117.
- [14]D A, Prince,C F, Stevens.Adenosine decreases neurotransmitter release at central synapses.[J].1992,89.
- [15]Y A, Mei,H, Vaudry,L, Cazin.Inhibitory effect of adenosine on electrical activity of frog melanotrophs mediated through A1 purinergic receptors.[J].1994,481 ( Pt 2).