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INHIBITION OF GABA-ACTIVATED CURRENTS IN ISOLATED RAT DRG NEURONS BY BRADYKININ
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0371-0874.1998.04.003
- Key Word:
- 缓激肽;γ-氨基丁酸A受体;背根神经节;全细胞膜片箝
Abstract： 本文应用全细胞膜片箝技术在新鲜分离的大鼠背根神经节(DRG)神经元上研究缓激肽(BK)对γ-氨基丁酸(GABA)反应的调制作用.结果发现:在34个对GABA反应的细胞中有31个细胞对BK敏感.在对BK敏感并引起内向电流的27个细胞中预加BK,对GABA-激活电流具有明显的抑制作用,如10-6mol/L的BK可抑制GABA(10-4mol/L)激活电流30%.BK可将GABA量效曲线明显下移,并抑制其最大反应达1/3以上,而不改变其Kd值.结果提示:BK能非竞争性地抑制GABA反应.
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