You Position: Home > Paper
EFFECT OF ORPHANIN FQ ON ACUPUNCTURE ANALGESIA AND NOXIOUS STIMULATION IN THE PERIAQUEDUCTAL GRAY
( views:183, downloads:8 )
- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1998.03.004
- Key Word:
- 孤啡肽;μ阿片受体;中脑导水管周围灰质;针刺镇痛;痛
Abstract： 孤啡肽(orphanin FQ,OFQ)是新近发现的神经肽,结构与内阿片肽相似,但作用明显不同.本文采用脑核团内微量注射方法,在大鼠电刺激甩尾测痛模型上,观察0FQ在中脑导水管周围灰质(PAG)内对痛和针刺镇痛的影响.结果表明:PAG内微量注射OFQ可使大鼠痛阈降低,并明显对抗针刺镇痛;另外还发现,0FQ在PAG内还可以对抗μ受体激动剂羟甲芬太尼加强针刺镇痛的效应.本文结果提示,OFQ在PAG内加强动物的痛感受,对抗针刺镇痛.
- [1]ZHU CB,Zhang XL,Xu SF,etc.Antagonistic effect of orphanin FQ on opioid analgesia in rat[J].1998,(1).
- [2]Zhu, Chong-Bin,Xu, Shao-Fen,Cao, xiao-Ding,etc.Antagonistic Action of Orphanin Fq on Acupuncture Analgesia in Rat Brain[J].1996,21(3-4).
- [3]Reinscheid, Rainer K.,Nothacker, Hans-Peter.Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor.[J].1995,270(5237).
- [4]L F, He.Involvement of endogenous opioid peptides in acupuncture analgesia.[J].1987,31.
- [5]K, TSOU,C S, JANG.Studies on the Site of Analgesic Action of Morphine by Intracerebral Micro-Injection.[J].1964,13.
- [6]Vaughan CW,Ingram SL,Christie MJ.Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro.[J].1997,17(3).
- [7]J, Hughes,T W, Smith,H W, Kosterlitz,etc.Identification of two related pentapeptides from the brain with potent opiate agonist activity.[J].1975,258.
- [8]J C, Meunier,C, Mollereau,L, Toll,etc.Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.[J].1995,377(6549).