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GABA MEDIATED INHIBITORY EFFECT OF AMYGDALA ON THE ACTIVITY OF MEDIAL GENICULATE BODY NEURONS
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- Author:
- No author available
- Journal Title:
- ACTA PHYSIOLOGICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0371-0874.1998.03.003
- Key Word:
- 杏仁体;抑制;内膝体;GABA
Abstract： 本文采用多管微电极胞外记录技术观察了短纯音引起兔内膝体(MGB)神经元的声反应及刺激杏仁体对声反应的影响,并在此基础上观察电泳GABA及其拮抗剂Bicuculline的效应.实验结果表明:GABA可以抑制MGB神经元的声反应及自发放电活动,而GABAA拮抗剂Bicuculline的作用则相反;电泳GABA对MGB神经元产生同刺激杏仁体一样的抑制效应,并且这种影响可被Bicuculline翻转;嗅鼻沟后缘听区皮层(auditory cortex behind the rhinal sulcus,ACBRS)区对MGB神经元的下行抑制也可由于电泳Bicuculline而消失,但甘氨酸拮抗剂Strychnine则无任何影响.由此推断:介导杏仁体抑制MGB神经元声反应的最终递质是GABA.
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